Catalog No.
YHA24001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys1042-Trp1205
Predicted molecular weight
21.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14607
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone demethylase UTY, 1.14.11.68, Ubiquitously-transcribed TPR protein on the Y chromosome, Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase UTY, UTY, KDM6C
UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia., PMID:40372430
Uncovering potential molecular markers and pathological mechanisms of Parkinson's disease and myocardial infarction based on bioinformatics analysis., PMID:39973855
Systematic identification of Y-chromosome gene functions in mouse spermatogenesis., PMID:39847625
Target cleavage and gene silencing by Argonautes with cityRNAs., PMID:39368090
Comprehensive Analysis of Juvenile Nasopharyngeal Angiofibromas via Whole-Exome Sequencing., PMID:39297564
Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure., PMID:39183958
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation., PMID:39048311
Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium., PMID:38580969
Where Are the Formerly Y-linked Genes in the Ryukyu Spiny Rat that has Lost its Y Chromosome?, PMID:38478711
Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features., PMID:38347332
Bladder Cancer, Loss of Y Chromosome, and New Opportunities for Immunotherapy., PMID:38198042
Transcriptomics profiling reveal the heterogeneity of white and brown adipocyte., PMID:37906396
Context-Dependent Functions of KDM6 Lysine Demethylases in Physiology and Disease., PMID:37751139
UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death., PMID:36412518
Integrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion., PMID:36323676
A dUTY to Protect: Addressing "Y" We See Sex Differences in Pulmonary Hypertension., PMID:35549630
Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines., PMID:35504005
Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§., PMID:35481403
AZFa candidate gene UTY and its X homologue UTX are expressed in human germ cells., PMID:35128450
Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype., PMID:34780480
JMJD3 deficiency alleviates lipopolysaccharide‑induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2‑dependent manner., PMID:34542160
UTX condensation underlies its tumour-suppressive activity., PMID:34526716
cg04448376, cg24387542, cg08548498, and cg14621323 as a Novel Signature to Predict Prognosis in Kidney Renal Papillary Cell Carcinoma., PMID:33381555
Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells., PMID:33040644
Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells., PMID:32913328
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer., PMID:32817139
X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis., PMID:32732223
The plasma peptides of sepsis., PMID:32636717
Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion., PMID:32353257
Specific expression and alternative splicing of mouse genes during spermatogenesis., PMID:32211685
Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis., PMID:31904996
Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes., PMID:31877875
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis., PMID:31644355
Comparison of mRNA expression from Y-chromosome X-degenerate region genes in taurine cattle, yaks and interspecific hybrid bulls., PMID:31475374
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches., PMID:31244373
Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation., PMID:31097364
The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction., PMID:30458291
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs., PMID:29736013
Subretinal Injection of HY Peptides Induces Systemic Antigen-Specific Inhibition of Effector CD4+ and CD8+ T-Cell Responses., PMID:29662488
UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling., PMID:29551674
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors., PMID:29533787
UTX - moonlighting in the cytoplasm?, PMID:29421189
Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila., PMID:29247011
UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome., PMID:29073101
Computational Analysis of High Risk Missense Variant in Human UTY Gene: A Candidate Gene of AZFa Sub-region., PMID:29062794
Y Chromosome Missing Protein, TBL1Y, May Play an Important Role in Cardiac Differentiation., PMID:28853286
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells., PMID:28150810
Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing., PMID:28132772
Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer., PMID:27533081
Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation., PMID:27339988
For research use only. Not for human or drug use.
