Catalog No.
YHA23201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser91-Glu260
Predicted molecular weight
21.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14593
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, RFX-B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, ANKRA1, RFXB
A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis., PMID:39358623
New mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency., PMID:39136810
MHC Class II Deficiency: Clinical, Immunological, and Genetic Insights in a Large Multicenter Cohort., PMID:38996837
Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis., PMID:38424321
The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication., PMID:37604847
Clinical, Immunological, and Genetic Findings in Iranian Patients with MHC-II Deficiency: Confirmation of c.162delG RFXANK Founder Mutation in the Iranian Population., PMID:37584719
Prediction of Weight Loss to Decrease the Risk for Type 2 Diabetes Using Multidimensional Data in Filipino Americans: Secondary Analysis., PMID:37040172
Haploidentical CD3+ TCR αβ/CD19+-depleted HSCT for MHC class II deficiency and persistent SARS-CoV-2 pneumonitis., PMID:36210925
Ciliary and immune dysfunctions and their genetic background in patients with non-cystic fibrosis bronchiectasis in Central Iran., PMID:35389161
Construction and validation of a transcription factors-based prognostic signature for ovarian cancer., PMID:35227285
Lessons learned from the diagnostic work-up of a patient with the bare lymphocyte syndrome type II., PMID:35065305
The transcription factor RFX5 positively regulates expression of MHCIa in the red-spotted grouper (Epinephelus akaara)., PMID:35051562
Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma., PMID:34505128
Genetic Screening of the Patients with Primary Immunodeficiency by Whole-Exome Sequencing., PMID:33406023
HLA-DR covers Bare Lymphocyte Syndrome., PMID:32875602
A Novel RFXANK Mutation in a Chinese Child With MHC II Deficiency: Case Report and Literature Review., PMID:32875002
A novel mutation in RFXANK gene and low B cell count in a patient with MHC class II deficiency: a case report., PMID:32578129
Structural basis for the recognition of RFX7 by ANKRA2 and RFXANK., PMID:31864703
Neuronal NLRC5 regulates MHC class I expression in Neuro-2a cells and also during hippocampal development., PMID:31549732
Persisting enteropathy and disturbed adaptive mucosal immunity due to MHC class II deficiency., PMID:31028919
MHC Class II Deficiency with Normal CD4+ T Cell Counts: A Case Report., PMID:30644704
MHC-II Deficiency Among Egyptians: Novel Mutations and Unique Phenotypes., PMID:30170160
A caspase-2-RFXANK interaction and its implication for MHC class II expression., PMID:29362422
MHC class II associated stomach cancer mutations correlate with lack of subsequent tumor development., PMID:29285385
MHC class II deficiency: Report of a novel mutation and special review., PMID:28676232
Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child., PMID:28508932
Different Immunological Pathways Underlie the Immune Response to Pneumococcal Polysaccharides., PMID:28303442
Major Histocompatibility Complex Class II Deficiency due to a Novel Mutation in RFXANK in a Child of Mexican Descent., PMID:26634365
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module., PMID:25811463
Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8., PMID:25752541
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex., PMID:25740990
MHC class I and II deficiencies., PMID:25001848
Clinical, immunological and genetic findings of a large tunisian series of major histocompatibility complex class II deficiency patients., PMID:23314770
Microarray analysis revealed that immunity-associated genes are primarily regulated by roxarsone in promoting broiler chicken (Gallus gallus domesticus) growth., PMID:23155029
Major histocompatibility complex class II deficiency in Kuwait: clinical manifestations, immunological findings and molecular profile., PMID:23143406
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock., PMID:22649097
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression., PMID:22490869
Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients., PMID:21908431
DNA binding domain of RFX5: interactions with X-box DNA and RFXANK., PMID:20637319
The 752delG26 mutation in the RFXANK gene associated with major histocompatibility complex class II deficiency: evidence for a founder effect in the Moroccan population., PMID:20414676
MHC class II deficiency cured by unrelated mismatched umbilical cord blood transplantation: case report and review of 68 cases in the literature., PMID:20214747
The locus control region of the MHC class II promoter acts as a repressor element, the activity of which is inhibited by CIITA., PMID:19897249
RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells., PMID:19465385
Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5., PMID:18723135
Characterization of the RFX complex and the RFX5(L66A) mutant: implications for the regulation of MHC class II gene expression., PMID:17279624
Human leucocyte antigen-identical haematopoietic stem cell transplantation in major histocompatiblity complex class II immunodeficiency: reduced survival correlates with an increased incidence of acute graft-versus-host disease and pre-existing viral infections., PMID:16848795
Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK., PMID:16236793
New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study., PMID:16166641
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases., PMID:15964851
Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2., PMID:15655668
For research use only. Not for human or drug use.
