Catalog No.
YHA21401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser616-Cys889
Predicted molecular weight
32.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14526
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
F-BAR domain only protein 1, FCHO1, KIAA0290
Laminar organization of molecular complexes in a clathrin coat revealed by nanoscale protein colocalization., PMID:40273906
Human FCHO1 deficiency: review of the literature and additional two cases., PMID:39498505
The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast., PMID:39316607
Comprehensive exploration of FCHO1 mutations: Clinical manifestations and implications across disorders., PMID:39166479
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy., PMID:39152475
A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer's disease., PMID:38915309
LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src., PMID:38742902
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy., PMID:38234807
Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance., PMID:37805492
Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis., PMID:36338652
Genomic characteristics of two breast malignant phyllodes tumors during pregnancy and lactation identified through whole-exome sequencing., PMID:36271373
circFCHO2 promotes gastric cancer progression by activating the JAK1/STAT3 pathway via sponging miR-194-5p., PMID:35708677
Induced nanoscale membrane curvature bypasses the essential endocytic function of clathrin., PMID:35532382
Structural organization and dynamics of FCHo2 docking on membranes., PMID:35044298
FCH domain only 1 (FCHo1), a potential new biomarker for lung cancer., PMID:34413495
Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease., PMID:34151536
Inflammatory Bowel Disease and Guillain Barre Syndrome in FCHO1 Deficiency., PMID:33950325
Liquid-like protein interactions catalyse assembly of endocytic vesicles., PMID:33820972
Identification of genetic loci jointly influencing coronary artery disease risk and sleep traits of insomnia, sleep duration, and chronotype., PMID:32846279
JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma., PMID:32570038
FCHO1560-571 peptide, a PKB kinase motif, inhibits tumor progression., PMID:32507602
Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells., PMID:32098969
A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation., PMID:31038455
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects., PMID:30822429
SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis., PMID:30236986
NECAPs are negative regulators of the AP2 clathrin adaptor complex., PMID:29345618
Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif., PMID:28701344
Eps15 membrane-binding and -bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis., PMID:27385343
Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding., PMID:27237791
Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain., PMID:26822536
The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex., PMID:25303366
A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing., PMID:25303365
Initiation of clathrin-mediated endocytosis: all you need is two?, PMID:23440851
The first five seconds in the life of a clathrin-coated pit., PMID:22863004
Fishing for clathrin-coated pit nucleators., PMID:22552146
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning., PMID:22484487
Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources., PMID:21883765
A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis., PMID:21445324
[Nucleation of clathrin-coated pits - « membrane sculptors » at work]., PMID:21382316
Cell biology: How to don a coat., PMID:20520699
FCHo proteins are nucleators of clathrin-mediated endocytosis., PMID:20448150
The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation., PMID:19962315
Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation., PMID:19713939
Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation., PMID:17617719
Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico., PMID:15254787
For research use only. Not for human or drug use.
