Catalog No.
YHA17901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp282-Asp465
Predicted molecular weight
23.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00635
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase TRIM38, 2.3.2.27, RING finger protein 15, Tripartite motif-containing protein 38, Zinc finger protein RoRet, TRIM38, RNF15, RORET
Identification of TRIM21 and TRIM14 as Antiviral Factors Against Langat and Zika Viruses., PMID:40431659
Characterization and Functional Analysis of Trim38 in the Immune Response of the Large Yellow Croaker (Larimichthys crocea) Against Pseudomonas plecoglossicida Infection., PMID:40362389
The Brucella Effector Protein BspF Crotonylates TRIM38 to Inhibit NF-κB and MAPK Signaling Pathway., PMID:40332097
Trim38 attenuates pressure overload‑induced cardiac hypertrophy by suppressing the TAK1/JNK/P38 signaling pathway., PMID:40314083
E3 ubiquitin ligase TRIM38 regulates macrophage polarization to reduce hepatic inflammation by interacting with HSPA5., PMID:40300357
Di-(2-ethylhexyl)-phthalate disrupts mouse placental growth by regulating the cell cycle of mouse placental trophoblasts through the Trim38-p53 signaling axis., PMID:40059473
TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway., PMID:40047371
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein., PMID:40006954
UBE2G2 inhibits vasculogenic mimicry and metastasis of uveal melanoma by promoting ubiquitination of LGALS3BP., PMID:39807310
Response of bovine endometrium to interferon tau in the presence of lipopolysaccharide., PMID:39180888
Active fraction of Polyrhachis vicina (Rogers) inhibits osteoclastogenesis by targeting Trim38 mediated proteasomal degradation of TRAF6., PMID:39033726
TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I., PMID:38630167
Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface., PMID:38012139
Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families., PMID:37696853
TRIM38 suppresses migration, invasion, metastasis, and proliferation in non-small cell lung cancer (NSCLC) via regulating the AMPK/NF-κB/NLRP3 pathway., PMID:37566200
Dose- and time-dependent effects of interferon tau on bovine endometrial gene expression., PMID:37549523
Triple motif proteins 19 and 38 correlated with treatment responses and HBsAg clearance in HBeAg-negative chronic hepatitis B patients during peg-IFN-α therapy., PMID:37475028
Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation., PMID:37116711
The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy., PMID:36623352
TRIM38 protects H9c2 cells from hypoxia/reoxygenation injury via the TRAF6/TAK1/NF-κB signalling pathway., PMID:36061751
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren's syndrome., PMID:35022662
TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer., PMID:34906161
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling., PMID:34426118
Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity., PMID:34177938
Evaluating the biological functions of the prognostic genes identified by the Pathology Atlas in bladder cancer., PMID:33200223
Investigating genetic drivers of dermatomyositis pathogenesis using meta-analysis., PMID:33015383
Identification of tumor microenvironment-related genes in lower-grade gliomas by mining TCGA database., PMID:35117823
TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation., PMID:29753717
Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization., PMID:29463848
NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes., PMID:28295271
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5., PMID:28250012
Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation., PMID:28211536
Multifaceted roles of TRIM38 in innate immune and inflammatory responses., PMID:28194022
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus., PMID:27637147
Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity., PMID:26636433
TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms., PMID:26392463
TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3., PMID:24434549
TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation., PMID:23056470
Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1., PMID:22539786
E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages., PMID:22323536
[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]., PMID:21789858
Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase., PMID:21306652
Quantitative analysis of human tissue-specific differences in methylation., PMID:18805397
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium., PMID:9288758
A 1.1-Mb transcript map of the hereditary hemochromatosis locus., PMID:9149941
For research use only. Not for human or drug use.
