Catalog No.
YHN53701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys66-Gln343
Predicted molecular weight
34.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y625
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glypican-6, GPC6
Molecular architecture of human atherosclerosis revealed through integrative human genetics., PMID:40093223
Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation., PMID:39871249
TRPC3-mediated NFATc1 calcium signaling promotes triple negative breast cancer migration through regulating glypican-6 and focal adhesion., PMID:39436410
Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms., PMID:39325545
Can Glypican-6 Levels Be Used to Determine Right Ventricular Remodeling After Non-ST Segment Elevation Myocardial Infarction?, PMID:38982813
Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts., PMID:38786073
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development., PMID:38750698
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits., PMID:37864255
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer., PMID:37410084
Five siblings expand the spectrum of GPC6-related skeletal dysplasia., PMID:37353964
Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury., PMID:37072558
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior., PMID:36944188
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle., PMID:36901723
Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling., PMID:36057966
Molecular Signatures Correlated With Poor IVF Outcomes: Insights From the mRNA and lncRNA Expression of Endometriotic Granulosa Cells., PMID:35295989
The function of glypicans in the mammalian embryo., PMID:35235423
Identification of novel candidate genes for age at first calving in Nellore cows using a SNP chip specifically developed for Bos taurus indicus cattle., PMID:34392169
Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma., PMID:33902495
Feingold syndrome type 2 in a patient from China., PMID:33818875
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6., PMID:33762006
Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients., PMID:33742285
Can Glypican-6 Level Predict Ejection Fraction Decline After Myocardial Infarction?, PMID:33094648
Hedgehog signaling activation required for glypican-6-mediated regulation of invasion, migration, and epithelial-mesenchymal transition of gastric cancer cells., PMID:32478377
An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population., PMID:32398079
Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., PMID:32019583
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation., PMID:31932507
Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling., PMID:31756413
[Effect of PR-957 on the formation of A1 reactive astrocytes]., PMID:31753094
Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification., PMID:31731208
Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma., PMID:31199813
Association of glypican-6 polymorphisms with lumbar disk herniation risk in the Han Chinese population., PMID:31111662
Pathogenic Variants in GPC4 Cause Keipert Syndrome., PMID:30982611
The plasma peptides of ovarian cancer., PMID:30598658
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish., PMID:29203233
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis., PMID:28869591
Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling., PMID:28696225
Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate., PMID:28281525
Hypoxia-induced HIF1α targets in melanocytes reveal a molecular profile associated with poor melanoma prognosis., PMID:28168807
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling., PMID:27768722
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome., PMID:27693046
Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination., PMID:26722758
Emerging role of microRNAs in lipid metabolism., PMID:26579440
Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival., PMID:26448945
Whole-genome association analysis of treatment response in obsessive-compulsive disorder., PMID:25824302
T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders., PMID:25600067
DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes., PMID:24811787
Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line., PMID:24804215
Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling., PMID:24496449
Long-term observation of a patient with dominant omodysplasia., PMID:24458798
The role of glypicans in Hedgehog signaling., PMID:24412155
For research use only. Not for human or drug use.
