Anti-EIF2AK3 Polyclonal Antibody

Catalog No.

PHK05001

Species reactivity

Human, Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human EIF2AK3 (Phe593-Phe1077).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

EIF2AK3, HsPEK, PERK, PEK, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, Eukaryotic translation initiation factor 2-alpha kinase 3

Purification

Purified by antigen affinity column.

Accession

Q9NZJ5

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5., PMID:38272235

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons., PMID:33341442

PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus., PMID:32197325

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway., PMID:30654386

Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy's Pathogenesis., PMID:30647798

A Flow Cytometric Study of ER Stress and Autophagy., PMID:30451364

New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review., PMID:30134550

Anti-ganglioside GD2 monoclonal antibody synergizes with cisplatin to induce endoplasmic reticulum-associated apoptosis in osteosarcoma cells., PMID:29442009

Nrf2 protects human lens epithelial cells against H2O2-induced oxidative and ER stress: The ATF4 may be involved., PMID:29421327

Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells., PMID:28601430

Endoplasmic reticulum stress pathway PERK-eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF-κB., PMID:28418119

HMGB1 induces endothelial progenitor cells apoptosis via RAGE-dependent PERK/eIF2α pathway., PMID:28251435

Molecular signal networks and regulating mechanisms of the unfolded protein response., PMID:28070992

Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells., PMID:26917416

Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2α pathway., PMID:26472187

Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase., PMID:26172286

Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A., PMID:25794107

Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus., PMID:25226532

Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells., PMID:24530917

Short stature in child with early-onset diabetes., PMID:23644647

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