Catalog No.
YHD77301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
[Asp2-Asn75] & [Phe255-Val324]
Predicted molecular weight
18.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28223
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5-HT-2A, 5-hydroxytryptamine receptor 2A, Serotonin receptor 2A, HTR2A, 5-HT-2, HTR2
Temporomandibular joint disorders, happiness, and COMT, HTR2A and FKBP5 polymorphisms in adolescents: a cross-sectional study., PMID:40435063
Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats., PMID:40429970
Hippocampal Zkscan4 confers resilience to chronic stress-induced depression-like behaviors., PMID:40408492
Maternal high-fat diet exposure impairs LKB1-TGFβ1 inflammatory pathway and increases hypothalamic 5HT receptors gene expression and somatic growth in young rats., PMID:40381902
Effects of lactoferrin on high-fat and high-cholesterol diet-induced non-alcoholic fatty liver disease in mice., PMID:40294723
Neurotransmitter 5-HT Further Promotes LL-37-Induced Rosacea-like Inflammation Through HTR3A., PMID:40243950
Daily acute intermittent hypoxia elicits age & sex-dependent changes in molecules regulating phrenic motor plasticity., PMID:40204197
Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro., PMID:40202572
Characterization of the Molecular Mechanisms Underlying Lurasidone-Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach., PMID:40202273
Serotonin 3 receptor antagonism reduces angiotensin II-induced abdominal aortic aneurysms: Contribution of periaortic fat-derived serotonin., PMID:40023595
Exploring therapeutic potential of Bacopa monnieri bioactive compounds against Alzheimer's and Parkinson's diseases., PMID:39959708
Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China., PMID:39889837
Polysaccharides from Scrophularia ningpoensis Hemsl. improve reserpine-induced depression-like behavior by inhibiting HTR2A/HTR2C mediated AKT/GSK3β/β-catenin/CBP/BDNF signalling., PMID:39884598
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis., PMID:39839219
Long-Term Exposure to Tire-Derived 6-PPD Quinone Causes Neurotoxicity and Neuroinflammation via Inhibition of HTR2A in C57BL/6 Mice., PMID:39810414
5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response., PMID:39766808
Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer., PMID:39760275
Effect of serotonin receptor gene variants on substance use disorders., PMID:39731452
GENETIC VARIANTS IN ANTIPSYCHOTIC METABOLISM: POLYMORPHISM PROFILES IN KAZAKH COHORT WITH PARANOID SCHIZOPHRENIA., PMID:39724888
Exploring the potential pharmacological mechanism of aripiprazole against hyperprolactinemia based on network pharmacology and molecular docking., PMID:39511179
Mood disorders and 5-HTR2A genetic variants - the moderator effect of inflammation on expression of affective polarity phenotype., PMID:39472813
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis., PMID:39436634
Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling., PMID:39423037
Multi-target Mechanisms of Si-Ni-San on Anxious Insomnia: An Example of Network-pharmacology and Molecular Docking Analysis., PMID:39410900
Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder., PMID:39407134
Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs., PMID:39405910
Psychedelic LSD activates neurotrophic signal but fails to stimulate neural stem cells., PMID:39256856
Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren., PMID:39203776
Exploring Candidate Gene Studies and Alexithymia: A Systematic Review., PMID:39202385
The serotonin(5-HT)2A receptor is involved in the hypersensitivity of bladder afferent neurons in cyclophosphamide-induced cystitis., PMID:39154826
Harmine promotes megakaryocyte differentiation and thrombopoiesis by activating the Rac1/Cdc42/JNK pathway through a potential target of 5-HTR2A., PMID:39152726
Sertraline Alleviates Chronic Prostatitis by Regulating the TRPV1 Channel., PMID:38979434
Sex and Age Differences in Ontogeny of Alloparenting: A Relation to Forebrain DRD1, DRD2, and HTR2A mRNA Expression?, PMID:38973227
Genetic polymorphisms in the 5-HT and endocannabinoid systems moderate the association between childhood trauma and burnout in the general occupational population., PMID:38879068
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits., PMID:38811567
Single-nucleus RNA-seq identifies one galanin neuronal subtype in mouse preoptic hypothalamus activated during recovery from sleep deprivation., PMID:38703367
Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms., PMID:38678087
Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes., PMID:38674857
Association of serotonin receptor gene polymorphisms with anorexia nervosa: a systematic review and meta-analysis., PMID:38668826
Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint., PMID:38662111
The Association Between the 5-Hydroxytryptamine Receptor 2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the Iranian Kurdish Population., PMID:38657123
A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11., PMID:38640040
Broiler Heart Muscle Monoaminergic Receptors Alteration in Response to Chronic Heat Stress: Based on Transcription Analysis., PMID:38590690
Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study., PMID:38565988
Molecular mechanisms of quetiapine bidirectional regulation of bipolar depression and mania based on network pharmacology and molecular docking: Evidence from computational biology., PMID:38518857
Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety., PMID:38509093
The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism., PMID:38421437
Living, Heat-Killed Limosilactobacillus mucosae and Its Cell-Free Supernatant Differentially Regulate Colonic Serotonin Receptors and Immune Response in Experimental Colitis., PMID:38398793
BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia., PMID:38397229
Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study., PMID:38377518
For research use only. Not for human or drug use.
