Catalog No.
YHB32901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp217-Lys347
Predicted molecular weight
17.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75844
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FACE-1, Prenyl protein-specific endoprotease 1, CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, Zinc metalloproteinase Ste24 homolog, FACE1, STE24, ZMPSTE24
Structure Bioinformatics of Six Human Integral Transmembrane Enzymes and their AlphaFold3 Predicted Water-Soluble QTY Analogs: Insights into FACE1 and STEA4 Binding Mechanisms., PMID:39966220
Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?, PMID:37627243
Predicting Multi-Interfacial Binding Mechanisms of NLRP3 and ASC Pyrin Domains in Inflammasome Activation., PMID:33504150
Mandibuloacral dysplasia type B (MADB): a cohort of eight patients from Suriname with a homozygous founder mutation in ZMPSTE24 (FACE1), clinical diagnostic criteria and management guidelines., PMID:31856865
MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies., PMID:29696758
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing., PMID:29208544
New ZMPSTE24 (FACE1) mutations in patients affected with restrictive dermopathy or related progeroid syndromes and mutation update., PMID:24169522
A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases., PMID:23733187
Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress., PMID:22555846
Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue., PMID:21508412
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function., PMID:20805469
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging., PMID:20458013
HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?, PMID:20074077
[The role of parotid gland biopsy in early detection of lymphoma in primary Sjogren's syndrome]., PMID:19663187
Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice., PMID:19014358
[A-type lamins and progeroïd syndromes : persistent farnesylation with dramatic effects]., PMID:18950579
Accumulation of multiple forms of lamin A with down-regulation of FACE-1 suppresses growth in senescent human cells., PMID:17352743
Midfacial degloving--access to nasal cavity and paranasal sinuses lesions., PMID:16951847
Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy., PMID:16297189
From immature lamin to premature aging: molecular pathways and therapeutic opportunities., PMID:16258283
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation., PMID:16079796
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors., PMID:15843403
RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome., PMID:15671064
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24., PMID:15479156
Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy., PMID:15317753
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice., PMID:11923874
Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins., PMID:10373325
For research use only. Not for human or drug use.
