Catalog No.
YHE03101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser496-Arg700
Predicted molecular weight
25.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P33402
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2, 4.6.1.2, GUCY1A2, GUC1A2, GUCSA2
Integrated Transcriptomic and Metabolomic Analysis of Rat PASMCs Reveals the Underlying Mechanism for Pulmonary Arterial Hypertension., PMID:39901736
Soluble Guanylate Cyclase Dysfunction and Nitric Oxide Pathway in Chronic Rhinosinusitis With Nasal Polyps: Predictive Markers for Postoperative Recurrence., PMID:39473384
Heterozygous gain of function variant in GUCY1A2 may cause autonomous ovarian hyperfunction., PMID:38578777
Identification of key genes for atherosclerosis in different arterial beds., PMID:38503760
Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling., PMID:37667322
Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome., PMID:36506088
Identification of Diagnostic Markers in Infantile Hemangiomas., PMID:36504560
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing., PMID:35277538
NF-κB-Related Metabolic Gene Signature Predicts the Prognosis and Immunotherapy Response in Gastric Cancer., PMID:35036435
Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer., PMID:34016083
Identification of key genes associated with rheumatoid arthritis with bioinformatics approach., PMID:28767591
α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders., PMID:25373139
Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia., PMID:24581742
Dysfunctional nitric oxide signalling increases risk of myocardial infarction., PMID:24213632
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease., PMID:22751097
sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling., PMID:21536853
Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts., PMID:21212316
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates., PMID:20797390
Nitric oxide sensitive guanylyl cyclase activity decreases during cerebral postnatal development because of a reduction in heterodimerization., PMID:19895661
alpha(2)-Adrenoceptor agonist xylazine induces peripheral antinociceptive effect by activation of the L-arginine/nitric oxide/cyclic GMP pathway in rat., PMID:19389395
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon., PMID:18572161
Two autocrine pathways to regulate cyclic GMP synthesis in cultured human retinal pigment epithelial cells., PMID:18437032
The alpha2beta1 isoform of guanylyl cyclase mediates plasma membrane localized nitric oxide signalling., PMID:17643962
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation., PMID:17610859
Cerebellar localization of the NO-receptive soluble guanylyl cyclase subunits-alpha(2)/beta (1) in non-human primates., PMID:16819625
Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients., PMID:12395325
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase., PMID:11944922
For research use only. Not for human or drug use.
