Catalog No.
YME47401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Pro63-Ile242
Predicted molecular weight
23.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23979
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-HT3A, 5-hydroxytryptamine receptor 3, 5-HT-3, 5-HT3R, Serotonin receptor 3A, Serotonin-gated ion channel receptor, Htr3a, 5ht3, Htr3
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon., PMID:40279204
Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus., PMID:40272992
Delayed Upper Gastrointestinal Motility in Mice Treated with Oral Iron Tablets., PMID:40268466
Running Reverses Chronic Stress-Induced Changes in Serotonergic Modulation of Hippocampal Granule Cells and Altered Behavioural Responses., PMID:40165404
The Serotonergic Control of Play Fighting in Male Juvenile Hamsters: Opposite Effects of 5-HT1A and 5-HT3 Receptor Manipulations., PMID:40007060
[Current Status and Issue of Emesis and Vomiting Caused by Trastuzumab Deruxtecan]., PMID:39957220
Topological segregation of stress sensors along the gut crypt-villus axis., PMID:39939779
Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism., PMID:39936308
CYP2D6 genotype and associated 5-HT3 receptor antagonist outcomes: A systematic review and meta-analysis., PMID:39899439
Granisetron ameliorates doxorubicin-evoked nephrotoxicity via modulation of Nrf2 and TLR4/p38 MAPK/NLRP3 signals in rats., PMID:39855027
Toll-like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5-hydroxytryptaminergic neurotransmission., PMID:39842456
Investigating the Mechanisms Involved in Scopolamine-induced Memory Degradation., PMID:39736944
Ondansetron blocks fluoxetine effects in immature neurons in the adult rat piriform cortex layer II., PMID:39732189
CCK-expressing neurons in the NTS are directly activated by CCK-sensitive C-type vagal afferents., PMID:39509587
Sex influence on serotonergic modulation of the vascular noradrenergic drive in rats., PMID:39489611
The Role of the Insular Cortex and Serotonergic System in the Modulation of Long-Lasting Nociception., PMID:39451236
Rapidly Trading Down Depression's 3 Pillars to 5HT3-Receptors Through ECT or Psilocybin?, PMID:39378462
Unraveling the Interplay of 5-hydroxytryptamine-3 and N-methyl-d-aspartate Receptors in Seizure Susceptibility., PMID:39299250
The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU., PMID:39234104
Concept article: Antidepressant-induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3)., PMID:39218660
Decreases in mucosally-evoked tachykinin signaling pathways can explain age-related reductions in murine colonic motility patterns., PMID:39155460
TREM-1 inhibition or ondansetron administration ameliorates NLRP3 inflammasome and pyroptosis in traumatic brain injury-induced acute lung injury., PMID:39050170
2-(Piperidin-3-yl)phthalimides reduce classical markers of cellular inflammation in LPS-challenged RAW 264.7 cells and also demonstrate potentially relevant sigma and serotonin receptor affinity in membrane preparations., PMID:38996940
Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System., PMID:38981901
Collaborative action between noradrenergic and serotoninergic systems in peripheral antinociception in mice., PMID:38920106
Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry., PMID:38913422
Low-dose ondansetron: A candidate prospective precision medicine to treat alcohol use disorder endophenotypes., PMID:38876929
Lycopene alleviates BCG-induced depressive phenotypes in mice by disrupting 5-HT3 receptor - IDO1 interplay in the brain., PMID:38830456
5-HT receptors exert differential effects on seizure-induced respiratory arrest in DBA/1 mice., PMID:38820310
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors., PMID:38698207
Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT3 receptors and the gut microbiota., PMID:38636750
Enhancing the action of serotonin by three different mechanisms prevents spontaneous seizure-induced mortality in Dravet mice., PMID:38593237
Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways., PMID:38503897
Cholecystokinin-Induced Duodenogastric Bile Reflux Increases the Severity of Indomethacin-Induced Gastric Antral Ulcers in Re-fed Mice., PMID:38448762
Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway., PMID:38437957
Serotonin and the serotonin transporter in the adrenal gland., PMID:38408804
FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m6A-dependent stabilization of 5-HT3A mRNA in sensory neurons., PMID:38285939
Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders., PMID:38258770
Synthesis and preclinical evaluation of [11C]uPSEM792 for PSAM4-GlyR based chemogenetics., PMID:38253691
Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR., PMID:38185260
Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception., PMID:38108436
New characterization of dihydroergotamine receptor pharmacology in the context of migraine: utilization of a β-arrestin recruitment assay., PMID:38073648
Efficacy and safety of Aprepitant-containing triple therapy for the prevention and treatment of chemotherapy-induced nausea and vomiting: A meta-analysis., PMID:38013306
Efficacy and safety of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists in augmentation with selective serotonin reuptake inhibitors (SSRIs) in the treatment of moderate to severe obsessive-compulsive disorder: a systematic review and meta-analysis of randomized clinical trials., PMID:38012263
Involvement of the Spinal Serotonergic System in the Analgesic Effect of [6]-Shogaol in Oxaliplatin-Induced Neuropathic Pain in Mice., PMID:37895936
Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats., PMID:37714467
The preventive effect of 5-hydroxytryptamine-3 receptor antagonist on blood pressure reduction and postoperative nausea and vomiting during general anesthesia induction: A double-blinded, randomized controlled trial., PMID:37633042
Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates., PMID:37620158
D2 dopamine receptor-mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine., PMID:37539658
Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms., PMID:37509503
For research use only. Not for human or drug use.
