Catalog No.
YHB80701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly34-Ala557
Predicted molecular weight
61.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95970
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leucine-rich glioma-inactivated protein 1, Epitempin-1, LGI1, EPT, UNQ775/PRO1569
Clinical, Electroencephalogram and Imaging Characteristics of Patients With Anti-LGI1 Antibody Encephalitis: A Multicenter Cohort Study., PMID:40322833
Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study., PMID:40303411
Successful treatment of morvan syndrome with efgartigimod: report of two cases., PMID:40268813
Leucine-rich glioma-inactivated protein 1 antibody-positive limbic encephalitis in a patient with an early-stage asymptomatic breast cancer., PMID:40180343
Intravenous immunoglobulin as first-line acute treatment in adults with autoimmune encephalitis caused by antibodies to NMDAR, LGI1 and CASPR2., PMID:40131535
Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review., PMID:40116573
Microglial Activation Visualized by [18F]-DPA714 PET Is a Potential Marker of Severity and Prognosis for Anti-LGI1 Encephalitis., PMID:40052391
Capturing what matters: Patient-reported LGI1-ANTibody encephalitis outcome RatiNg scale (LANTERN)., PMID:39996410
Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models., PMID:39984135
Autoimmune encephalitis associated with anti-LGI1 antibody: a potential cause of neuropsychiatric systemic lupus erythematosus., PMID:39965877
Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes., PMID:39879565
Efgartigimod treatment for therapy-refractory autoimmune encephalitis with coexistent NMDAR and LGI1 antibodies: a case report and literature review., PMID:39820999
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts., PMID:39454566
Comparison of B Cell Variable Region Gene Segment Characteristics in Neuro-autoantibodies., PMID:39446034
Anti-leucine-rich Glioma-inactivated 1 Encephalitis Manifesting as Frequent Ictal Pouting and Subtle Memory Disturbance., PMID:39343577
[Clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis]., PMID:39322558
A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity., PMID:39301592
Cerebrospinal fluid soluble CD27 is a sensitive biomarker of inflammation in autoimmune encephalitis., PMID:39278170
Anti-LGI1 Antibody-Associated Encephalitis Misdiagnosed as Schizophrenia: A Case Report., PMID:39216106
Clonal hematopoiesis in LGI1-antibody encephalitis., PMID:39199016
LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening., PMID:39141878
LGI1 encephalitis: potentially complement-activating anti-LGI1-IgG subclasses 1/2/3 are associated with the development of hippocampal sclerosis., PMID:39105896
OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation., PMID:39083419
A Stitch in Time Saves Nine: A Case of Anti LGI1 Encephalitis Presenting as Goose Bumps., PMID:39041996
Premotor cortex involvement in faciobrachial dystonic seizures: A contribution from MEG-EMG study in a case of anti-LGI1 encephalitis., PMID:39032206
Familial mesial temporal lobe epilepsy phenotype is associated with novel LGI1 variants: A report of two families., PMID:39029408
Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug-resistant epilepsy., PMID:39012808
Postoperative brainstem cavernous malformations complicated with LGI1 encephalitis and hypertrophic olivary degeneration: A case report and literature review., PMID:38991392
Resolution of anti-LGI1-associated autoimmune encephalitis in a patient after treatment with efgartigimod., PMID:38981871
Two Cases of Pediatric Leucine-Rich Glioma-Inactivated Protein-1 Encephalitis: Clinical Course, Challenges, and Implications., PMID:38905745
MR Imaging Findings in Anti-Leucine-Rich Glioma Inactivated Protein 1 Encephalitis: A Systematic Review and Meta-analysis., PMID:38871367
Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABABR Antibodies: Implications for Return to Driving., PMID:38838283
Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission., PMID:38700985
LGI1-antibody encephalitis: how to approach this highly treatable dementia mimic in memory and mental health services., PMID:38699852
Mechanisms of autoimmune encephalitis., PMID:38667756
The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels., PMID:38663634
Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo., PMID:38662480
Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies., PMID:38648696
Origin and significance of leucine-rich glioma-inactivated 1 antibodies in cerebrospinal fluid., PMID:38551680
Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis., PMID:38497971
Leucine-Rich Glioma-Inactivated 1 (LGI1) Protein Stimulates Proliferation and IL-10 Production in Peripheral Blood Mononuclear Cells of Patients with LGI1 Antibody-Mediated Autoimmune Encephalitis In Vitro., PMID:38473828
[18F]DPA-714-PET-MRI reveals pronounced innate immunity in human anti-LGI1 and anti-CASPR2 limbic encephalitis., PMID:38472399
Neurological, psychiatric, and sleep investigations after treatment of anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis in Spain: a prospective cohort study., PMID:38365378
Sleep matters in anti-LGI1 encephalitis., PMID:38365361
Dissecting autoimmune encephalitis through the lens of intrathecal B cells., PMID:38354256
Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis., PMID:38319973
Antibody induced seizure susceptibility and impaired cognitive performance in a passive transfer rat model of autoimmune encephalitis., PMID:38035091
Acute Symptomatic Seizures and Risk of Seizure Recurrence in Patients with Anti-NMDAR, Anti-LGI1, and Anti-GABABR Encephalitis., PMID:37940748
Isaacs syndrome with LGI1 and CASPR2 antibodies after HPV vaccination: A case report., PMID:37933002
Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons., PMID:37863654
For research use only. Not for human or drug use.
