Catalog No.
YMN45401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ala28-Asn115
Predicted molecular weight
37.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8CFV4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuritin, Candidate plasticity gene 15 protein, Nrn1, Cpg15
Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy., PMID:40332354
NRN1 may Modulate Tau Phosphorylation and Neuronal Apoptosis in AD via the PIGU-CASP3 Axis., PMID:40296620
Neurotrophic factor neuritin ameliorates streptozotocin-induced Alzheimer's disease-like impairment of memory, neuroinflammation, apoptotic factors and compensates hippocampal neuritin expression., PMID:40127821
Bladder cancer detection in urine by novel methylation markers., PMID:39567591
Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity., PMID:39565188
Identification of Sequential Molecular Mechanisms and Key Biomarkers in Early Glaucoma by Integrated Bioinformatics Analysis., PMID:39495230
Neuritin attenuates neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via endoplasmic reticulum stress-related inflammatory pathways., PMID:39454807
Neuritin Controls Axonal Branching in Serotonin Neurons: A Possible Mediator Involved in the Regulation of Depressive and Anxiety Behaviors via FGF Signaling., PMID:39197941
Neuritin accelerates Schwann cell dedifferentiation via PI3K/Akt/mTOR signalling pathway during Wallerian degeneration., PMID:39187917
Expression of activity-regulated transcripts in pyramidal neurons across the cortical visuospatial working memory network in unaffected comparison individuals and individuals with schizophrenia., PMID:39033685
Preparation of recombinant neuritin protein., PMID:39002828
Neuritin 1 Drives Therapeutic Preservation of Retinal Ganglion Cells in an Ex Vivo Human Glaucoma Model., PMID:38995841
NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia., PMID:38720004
NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma., PMID:38705997
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage., PMID:38570154
Differential Gene Regulatory Network Analysis between Azacitidine-Sensitive and -Resistant Cell Lines., PMID:38542276
Exploring the molecular and immune-landscape of lung cancer associated with cystic airspaces., PMID:38430689
Neuritin Alleviates Diabetic Retinopathy by Regulating Endoplasmic Reticulum Stress in Rats., PMID:38173210
Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities., PMID:38165375
Integrative multi-omics analyses unravel the immunological implication and prognostic significance of CXCL12 in breast cancer., PMID:37564657
Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate., PMID:37249336
Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease., PMID:37024090
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches., PMID:35806464
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway., PMID:35038134
Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes., PMID:34946963
Proteomics and functional study reveal kallikrein-6 enhances communicating hydrocephalus., PMID:34915845
Clinicopathological and Preclinical Patient-Derived Model Studies Define High Expression of NRN1 as a Diagnostic and Therapeutic Target for Clear Cell Renal Cell Carcinoma., PMID:34804954
Neuritin attenuates oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by promoting autophagic flux., PMID:34536391
NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss., PMID:34530960
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity., PMID:34471224
Artificial intelligence and placental DNA methylation: newborn prediction and molecular mechanisms of autism in preterm children., PMID:34404318
LGI1 governs neuritin-mediated resilience to chronic stress., PMID:34401409
Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice., PMID:34058347
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer., PMID:33931924
Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury., PMID:33863396
Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway., PMID:33787845
Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction., PMID:33729996
Follicular regulatory T cells produce neuritin to regulate B cells., PMID:33711260
Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons., PMID:33678755
Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury., PMID:33323541
Exogenous neuritin treatment improves survivability and functions of Schwann cells with improved outgrowth of neurons in rat diabetic neuropathy., PMID:32667138
miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice., PMID:32626916
Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons., PMID:32609320
Nrn1 Overexpression Attenuates Retinal Ganglion Cell Apoptosis, Promotes Axonal Regeneration, and Improves Visual Function Following Optic Nerve Crush in Rats., PMID:32607759
HIF1α inhibitor 2-methoxyestradiol decreases NRN1 expression and represses in vivo and in vitro growth of patient-derived testicular germ cell tumor spheroids., PMID:32544513
Asiaticoside Inhibits Neuronal Apoptosis and Promotes Functional Recovery After Spinal Cord Injury in Rats., PMID:32529536
The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer., PMID:32285140
The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients., PMID:32157595
Decreased cpg15 augments oxidative stress in sleep deprived mouse brain., PMID:31787230
For research use only. Not for human or drug use.
