Catalog No.
VMD72101
Species reactivity
Mouse
Host species
Mouse
Isotype
IgG
Clonality
Monoclonal
Target
Bispecific, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, Klrk1, Nkg2d, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, Cd3e
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O54709 & P22646
Applications
FuncS
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0248
Synthetic NKG2D receptor (SNR) armored CAR-T cells overcome antigen heterogeneity of solid tumor., PMID:40536708
T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions., PMID:40534857
Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis., PMID:40534503
A fc-engineered NKG2D × B7-H3 bispecific antibody enhances the antitumor activity by orchestrating cytotoxic lymphocytes., PMID:40516256
Nivolumab plus relatlimab in advanced melanoma: RELATIVITY-047 4-year update., PMID:40513285
Harnessing NKG2D CAR-T cells with radiotherapy: a novel approach for esophageal squamous cell carcinoma treatment., PMID:40510363
Regulatory TCRαβ+ double negative T cells suppress γδ T cells and alleviate colitis., PMID:40505772
Exploring the correlation and mechanism of natural killer cell cytotoxic sensitivity against gastric cancer., PMID:40486876
Dysregulation of NK cell subsets and phenotypes in COVID-19 patients with comorbid type 2 diabetes., PMID:40471558
Myeloid cell IL-15 production in the brain supports Bystander CD8+ T-Cell Neuropathic Immune Responses following Virus infection., PMID:40462933
Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor., PMID:40458406
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia., PMID:40440957
Intraperitoneal infusion of NKG2D CAR-NK cells induces endogenous CD8+ T cell activation in patients with advanced colorectal cancer., PMID:40437757
Natural Killer Cell Activation Signature Identifies Cyclin B1/CDK1 as a Druggable Target to Overcome Natural Killer Cell Dysfunction and Tumor Invasiveness in Melanoma., PMID:40430484
Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia., PMID:40430040
Intratumoral Injection of Allogeneic NK Cell With Chemotherapy in a Triple-negative Breast Cancer Preclinical Model., PMID:40425335
Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase., PMID:40421029
NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells., PMID:40421025
Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALL., PMID:40416955
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV., PMID:40411624
IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways., PMID:40399368
Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines., PMID:40391211
N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells., PMID:40389988
Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374
Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib., PMID:40388487
Macrophage-derived pro-inflammatory cytokines augment the cytotoxicity of cytokine-induced killer cells by strengthening the NKG2D pathway in multiple myeloma., PMID:40369131
Protocol for in-plate staining of clinical peripheral blood mononuclear cell samples for high-throughput analysis via spectral flow cytometry., PMID:40347474
Higher CD16-NKp46bright uterine endometrial natural killer cells may predict pregnancy success in women experiencing recurrent reproductive failure., PMID:40318990
A multidimensional analysis of prognostic factors in atopic dermatitis., PMID:40313541
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory., PMID:40295473
Identifying Modifiers of CAR T-Cell Therapeutic Efficacy and Safety: A Systematic Review and Individual Patient Data Meta-Analysis., PMID:40280037
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand., PMID:40276759
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity., PMID:40274283
Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock., PMID:40254928
ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity., PMID:40243581
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer., PMID:40240620
Heterogeneity of γδ T-cell subsets and their clinical correlation in patients with AML., PMID:40236710
From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis., PMID:40236704
CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma., PMID:40234092
Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway., PMID:40213545
H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition., PMID:40207661
NKG2D ligand expression on NK cells induces NKG2D-mediated cross-tolerization of cytokine signaling and reduces NK cell tumor immunity., PMID:40199610
Spatial statistics of submicron size clusters of activating and inhibitory Natural Killer cell receptors in the resting state regulate early time signal discrimination., PMID:40196617
NKG2D/CD28 chimeric receptor boosts cytotoxicity and durability of CAR-T cells for solid and hematological tumors., PMID:40181405
Immune signatures and biomarkers of viral control in early-treated children with HIV: insights informing intervention., PMID:40171852
Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition., PMID:40170846
Immune profile and routine laboratory indicator-based machine learning for prediction of lung cancer., PMID:40168805
Enrichment of CD7+CXCR3+ CAR T-cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma., PMID:40132760
23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation., PMID:40116579
CD4+ anti-TGF-β CAR T cells and CD8+ conventional CAR T cells exhibit synergistic antitumor effects., PMID:40107245
For research use only. Not for human or drug use.
