Catalog No.
YXX16801
Expression system
E. coli
Species
Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Protein length
Met1-Phe591
Predicted molecular weight
69.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P75409
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 0.02% SKL, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ADP-ribosylating toxin CARDS, 2.4.2.-, ADP-ribosyltransferase CARDS, Community-Acquired Respiratory Distress Syndrome Toxin, CARDX TX, cards, MPN_372, MP464
Rapid detection of Mycoplasma pneumoniae CARDS toxin in clinical respiratory specimens by a loop-mediated isothermal amplification assay., PMID:40176984
[Protective effect of Streptococcus salivarius K12 against Mycoplasma pneumoniae infection in mice]., PMID:39725618
Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis., PMID:39257401
Exploring the pathogenicity of Mycoplasma pneumoniae: Focus on community-acquired respiratory distress syndrome toxins., PMID:39153578
Comparative genomic sequencing to characterize Mycoplasma pneumoniae genome, typing, and drug resistance., PMID:38904371
The Therapeutic Potential of Neutrophil Extracellular Traps and NLRP3 Inflammasomes in Mycoplasma pneumoniae Pneumonia., PMID:38874911
Observational retrospective clinical study on clinical features of macrolide-resistant Mycoplasma pneumoniae pneumonia in Chinese pediatric cases., PMID:38453960
The CARDS toxin of Mycoplasma pneumoniae induces a positive feedback loop of type 1 immune response., PMID:36532054
Characterization of a virulence-modifying protein of Leptospira interrogans identified by shotgun phage display., PMID:36519163
High Expression of MUC5AC, MUC5B, and Layilin Plays an Essential Role in Prediction in the Development of Plastic Bronchitis Caused by MPP., PMID:35770160
Investigation of the relationship between community-acquired respiratory distress syndrome toxin and the high-mobility group box protein 1-toll-like receptors-myeloid differentiation factor 88 signaling pathway in Mycoplasma pneumoniae pneumonia., PMID:35505407
Vaccine using community-acquired respiratory distress syndrome toxin as an antigen against Mycoplasma pneumoniae in mice., PMID:35078111
Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice., PMID:34937175
Mycoplasma pneumoniae CARDS toxin exploits host cell endosomal acidic pH and vacuolar ATPase proton pump to execute its biological activities., PMID:34078958
Evaluation of the CARDS toxin and its fragment for the serodiagnosis of Mycoplasma pneumoniae infections., PMID:33733396
Mycoplasma pneumoniae Infections: Pathogenesis and Vaccine Development., PMID:33503845
[Mycoplasma pneumoniae toxin of community-acquired respiratory distress syndrome (CARDS) promotes autophagy of THP-1 cells and activates NLRP3 inflammasomes]., PMID:33325360
Interleukin-23 derived from CD16+ monocytes drives IL-17 secretion by TLR4 pathway in children with mycoplasma pneumoniae pneumonia., PMID:32726660
Mycoplasma pneumoniae biofilms grown in vitro: traits associated with persistence and cytotoxicity., PMID:32421492
High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia., PMID:31399022
Detection of Mycoplasma pneumoniae in Mexican children with community-acquired pneumonia: experience in a tertiary care hospital., PMID:31118700
Disulfide bond of Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities., PMID:30977272
Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity., PMID:29362229
NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection., PMID:29061706
The Immunopathologic Effects of Mycoplasma pneumoniae and Community-acquired Respiratory Distress Syndrome Toxin. A Primate Model., PMID:28915064
Mycoplasma pneumoniae CARDS toxin elicits a functional IgE response in Balb/c mice., PMID:28199385
Inflammation-inducing Factors of Mycoplasma pneumoniae., PMID:27065977
Pathogenesis of Mycoplasma pneumoniae: An update., PMID:26776112
Hydrogen sulfide is a novel potential virulence factor of Mycoplasma pneumoniae: characterization of the unusual cysteine desulfurase/desulfhydrase HapE., PMID:26711628
Comparative "-omics" in Mycoplasma pneumoniae Clinical Isolates Reveals Key Virulence Factors., PMID:26335586
Mycoplasma iowae: relationships among oxygen, virulence, and protection from oxidative stress., PMID:25880161
Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae., PMID:25848012
ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity., PMID:25538194
Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells., PMID:25139904
Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammation in BALB/c mice., PMID:25058417
Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities., PMID:24948331
[Progress in studies on Mycoplasma pneumoniae-produced community-acquired respiratory distress syndrome toxin]., PMID:24267145
Mycoplasma pneumoniae CARDS toxin is internalized via clathrin-mediated endocytosis., PMID:23667510
Mycoplasma pneumoniae in children with acute and refractory asthma., PMID:23622002
Synthesis and distribution of CARDS toxin during Mycoplasma pneumoniae infection in a murine model., PMID:21957154
Cellular vacuoles induced by Mycoplasma pneumoniae CARDS toxin originate from Rab9-associated compartments., PMID:21829543
Persistence of community-acquired respiratory distress syndrome toxin-producing Mycoplasma pneumoniae in refractory asthma., PMID:21622549
Novel toxin assays implicate Mycoplasma pneumoniae in prolonged ventilator course and hypoxemia., PMID:20884727
Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among mycoplasma pneumoniae strains., PMID:20508214
Crystallization of community-acquired respiratory distress syndrome toxin from Mycoplasma pneumoniae., PMID:20208164
Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome toxin expression reveals growth phase and infection-dependent regulation., PMID:20199607
Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin., PMID:19859545
Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis., PMID:19638108
For research use only. Not for human or drug use.
