Catalog No.
YHA36101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala129-Ser403
Predicted molecular weight
33.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14965
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aurora kinase A, 2.7.11.1, Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers., PMID:40501675
BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potential., PMID:40471223
The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach., PMID:40430485
Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome., PMID:40424049
Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin b1-induced hepatocellular carcinoma., PMID:40392001
Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis., PMID:40389989
AUNIP was a candidate marker for prognosis and immunology in pan-cancer., PMID:40386627
Razing the scaffolding: the elimination of non-catalytic functions of kinases through targeted protein degradation., PMID:40386346
Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor., PMID:40378279
N6-Methyladenosine Reader Protein YTHDC1 Supports Proper Mitotic Progression Partly through Regulation of TPX2-Aurora A Signaling., PMID:40368827
First-in-class dual inhibitors of MASTL and Aurora A kinase: Discovery of selective cyclohexa[b]thiophenes with potent anticancer activity., PMID:40367676
Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors., PMID:40367180
Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology., PMID:40355485
A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis., PMID:40341916
CRISPR/Cas9-Mediated Knockout of BmGDAP2 in the Silkworm, Bombyx mori: Extended Lifespan and Altered Gene Expression Impacting Developmental Pathways., PMID:40332832
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation., PMID:40328643
Identification and validation of hub genes in uterine corpus endometrioid carcinoma: An observational study from TCGA and GEO., PMID:40324248
Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning., PMID:40317315
[Aurora-A overexpression promotes cervical cancer cell invasion and metastasis by activating the NF-κBp65/ARPC4 signaling axis]., PMID:40294934
Molecular mechanisms of radiation resistance in colorectal cancer: in silico identification of AURKA, BIRC5 and PLK1 proteins as potential biomarkers., PMID:40293443
Network-Based Integrative Analysis to Identify Key Genes and Corresponding Reporter Biomolecules for Triple-Negative Breast Cancer., PMID:40287845
SETD2 loss of function is a recurrent event in advanced-phase chronic myeloid leukemia and contributes to genomic instability: SETD2 loss in Chronic Myeloid Leukemia., PMID:40275711
Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia., PMID:40260377
Identification of novel AURKA inhibitors against neuroblastoma using a virtual screening approach., PMID:40253760
Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule., PMID:40247090
RAD51 expression and prognostic impact in patients with stomach adenocarcinoma., PMID:40231067
Proximity-based activation of AURORA A by MPS1 potentiates error correction., PMID:40203828
Single-Cell Profiling and Proteomics-Based Insights Into mTORC1-Mediated Angio+TAMs Polarization in Recurrent IDH-Mutant Gliomas., PMID:40202138
Identifying ribonucleotide reductase subunit genes as potential lung adenocarcinomas biomarkers using integrated bioinformatics analysis., PMID:40191558
The role of insulin receptor InR in photoperiod-regulated reproductive diapause of Chrysoperla nipponensis., PMID:40158640
Computational identification and experimental characterization of an aurora kinase inhibitor., PMID:40156935
Breaking bottlenecks: the future of hepatocellular carcinoma clinical trials and therapeutic targets., PMID:40156659
O-Cyanobenzaldehydes Irreversibly Modify Both Buried and Exposed Lysine Residues in Live Cells., PMID:40150802
BRCA1 regulates glucose and lipid metabolism in diabetes mellitus with metabolic dysfunction-associated steatotic liver disease via the PI3K/Akt signaling pathway., PMID:40138287
Dual targeting of Aurora Kinase A and poly (ADP-ribose) polymerase as a therapeutic option for patients with ovarian cancer: preclinical evaluations., PMID:40138020
"Exploration of Novel Anticancerous Agents Targeting Human Aurora Kinase C"., PMID:40123311
[Characteristics of Aurora Kinase A-Mediated Tumor Microenvironment in Colorectal Cancer and Mining of Active Compounds From Chinese Herbs]., PMID:40109475
TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression., PMID:40107714
Broussoflavonol B induces S-phase arrest and apoptosis in pancreatic cancer cells by modulating the cell cycle checkpoint through inhibition of the AURKA/PLK1 pathway., PMID:40098146
Mechanisms of Picrasma quassioides against hepatocellular carcinoma elucidated by network pharmacology and experimental validation., PMID:40092104
Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo., PMID:40082489
Comprehensive bioinformatics analysis reveals key hub genes linked to prognosis in multiple myeloma with drug resistance., PMID:40068082
An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions., PMID:40057470
Suppressive role of fukutin on cell proliferation in uterine cervical carcinoma in relation to Aurora-A kinase., PMID:40034075
Analysis of ferroptosis-related key genes and regulatory networks in diabetic foot ulcers., PMID:40024299
Transferrin Receptor Promotes Endometrial Cancer Proliferation by Activating the Iron-Dependent PI3K/AKT/mTOR Signaling Pathway., PMID:40022544
Proteomic and phosphoproteomic analyses reveal the biological perturbations caused by capsaicin treatment., PMID:40022394
Targeting the AURKB-MAD2L2 Axis Disrupts the DNA Damage Response and Glycolysis to Inhibit Colorectal Cancer Progression., PMID:40018943
Targeting Aurora A to Overcome Cisplatin Resistance in Head and Neck Cancer., PMID:40017056
Identifying Sex Differences in Lung Adenocarcinoma Using Multi-Omics Integrative Protein Signaling Networks., PMID:39975108
For research use only. Not for human or drug use.
