Catalog No.
YMC83701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ala27-Phe573
Predicted molecular weight
60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P63038
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
60 kDa heat shock protein, mitochondrial, 5.6.1.7, 60 kDa chaperonin, Chaperonin 60, CPN60, HSP-65, Heat shock protein 60, HSP-60, Hsp60, Mitochondrial matrix protein P1, Hspd1, Hsp60
HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A., PMID:40463013
Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway., PMID:40448367
Heat shock protein D1 is up-regulated in various types of canine mammary tumors., PMID:40386101
Diminution of HSP75 disrupts intestinal epithelial barrier by inciting mPTP opening in ulcerative colitis., PMID:40294832
Depletion of HSP60 in Microglia Leads to Synaptic Dysfunction and Depression-Like Behaviors Through Enhanced Synaptic Pruning in Male Mice., PMID:40237297
Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death., PMID:40235440
Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states., PMID:40180932
Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells., PMID:40093510
Integrative analysis of serum proteomics and transcriptomics in hepatitis C., PMID:40082995
Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma., PMID:39991516
HSPD1-facilitated formation of CTPS cytoophidia promotes proliferation in C2C12 cells., PMID:39971178
Dihydrotanshinone I potentiates the anti-tumor activity of cisplatin by activating ROS-mediated ER stress through targeting HSPD1 in lung cancer cells., PMID:39952584
Increased intracellular stress responses and decreased KLF2 in adult patients with atopic dermatitis., PMID:39938773
Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma., PMID:39926543
Effects of in vitro cytochalasin D and hypoxia on mitochondrial energetics and biogenesis, cell signal status and actin/tubulin/Hsp/MMP entity in air-breathing fish heart., PMID:39864717
HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses., PMID:39709477
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer., PMID:39690273
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide., PMID:39637657
Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer., PMID:39623254
Proteomic analysis illustrates the potential involvement of dysregulated ribosome-related pathways and disrupted metabolism during retinoic acid-induced cleft palate development., PMID:39614345
Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers., PMID:39594201
snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk., PMID:39593105
Lung Single-Cell Transcriptomics Offers Insights into the Pulmonary Interstitial Toxicity Caused by Silica Nanoparticles., PMID:39568699
Proteomic identification of potential biomarkers for heat tolerance in Caracu beef cattle using high and low thermotolerant groups., PMID:39538142
The Spleen Modulates the Balance of Natural and Pathological Autoantibodies in a Mouse Model of Autoimmune Arthritis., PMID:39519235
The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing., PMID:39507528
Heterozygous de novo variants in HSPD1 cause hypomyelinating leukodystrophy through impaired HSP60 oligomerisation., PMID:39500555
Purification of functional recombinant human mitochondrial Hsp60., PMID:39488385
Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism., PMID:39452740
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling., PMID:39430254
Heat stress affects milk yield, milk quality, and gene expression profiles in mammary cells of Girolando cows., PMID:39343218
Tubeimoside-I, an inhibitor of HSPD1, enhances cytotoxicity of oxaliplatin by activating ER stress and MAPK signaling pathways in colorectal cancer., PMID:39208999
Oxysterol Induces Expression of 60 kDa Chaperone Protein on Cell Surface of Microglia., PMID:39201760
Liver Mitochondrial Morphology and Gene Expression as Markers of Liver Reserve: Prognostic Implications for Native Liver Survival in Biliary Atresia., PMID:39187420
Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways., PMID:39177530
HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis., PMID:39147275
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly., PMID:38951622
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response., PMID:38950333
Quantitative analysis of the lysine acetylome reveals the role of SIRT3-mediated HSP60 deacetylation in suppressing intracellular Mycobacterium tuberculosis survival., PMID:38916288
High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC)., PMID:38857914
Integrated analysis of muscle transcriptome, miRNA, and proteome of Chinese indigenous breed Ningxiang pig in three developmental stages., PMID:38808333
Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells., PMID:38767798
Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction., PMID:38663552
Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice., PMID:38588611
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma., PMID:38493408
Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant., PMID:38412855
Identification of HSPD1 as a novel invasive biomarker associated with mitophagy in pituitary adenomas., PMID:38290248
The Genetic Selection of HSPD1 and HSPE1 Reduce Inflammation of Liver and Spleen While Restraining the Growth and Development of Skeletal Muscle in Wuzhishan Pigs., PMID:38200905
Integrated Bioinformatic Analysis of Differentially Expressed Genes Associated with Wound Healing., PMID:38192258
For research use only. Not for human or drug use.
