Catalog No.
EHD75202
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu18-Leu417
Predicted molecular weight
49.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27797
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calreticulin, ERp60, CRTC, Calregulin, grp60, HACBP, Endoplasmic reticulum resident protein 60, CALR, CRP55
Studying Immunogenic Cell Death in Human Colorectal Cancer Organoids., PMID:40502372
Dexmedetomidine induces immunogenic cancer cell death and sensitizes tumors to PD-1 blockade., PMID:40480656
A rare CALR exon 9 mutation p.E379Vfs*53 in AYA generation exhibits gain-of-function nature and can induce essential thrombocythemia; a case report., PMID:40474352
Enhancing antitumor immunity via ROS-ERS and pyroptosis-induced immunogenic cell death in multiple myeloma., PMID:40473272
Design, Synthesis, and Evaluation of Pyrazolopyridine Derivatives as Novel Calreticulin (CALR) Ligands That Inhibit Triple-Negative Breast Cancer (TNBC) via Inducing Calcium Overloading., PMID:40464282
Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery., PMID:40463173
Patritumab deruxtecan induces immunogenic cell death., PMID:40458967
A novel calreticulin of Psoroptes ovis regulated keratinocyte function resulting in host skin barrier dysfunction: implications for involvement in the pathogenesis of psoroptic mange., PMID:40448127
An Endoplasmic Reticulum Stress-Specific Nanoinducer Selectively Evokes Type-II Immunogenic Cell Death for Pyroptotic Cancer Immunotherapy., PMID:40434207
Comparative Transcriptome Analysis Elucidates the Desiccation Stress Adaptation in Sargassum muticum., PMID:40428409
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors., PMID:40420289
Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltration., PMID:40417915
Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome., PMID:40407495
Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms., PMID:40403318
Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal., PMID:40397678
Partial mitochondrial involvement in the antiproliferative and immunostimulatory effects of PT-112., PMID:40386940
Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results., PMID:40386779
A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro., PMID:40369535
BiP, GRP94, calreticulin and calnexin contribute to development of the notochord in medaka fish., PMID:40368802
Differential regulation of mTORC2 signalling by type I and type II calreticulin (CALR) driver mutations of myeloproliferative neoplasm., PMID:40355863
Discovery of Cu(II)-Dipyridophenazine Complex for Synergistic Cuproptosis/Chemodynamic Therapy via Disrupting the Tricarboxylic Acid (TCA) Cycle in Metastatic TNBC., PMID:40348584
Combined exposure to atrazine and phoxim exacerbated the alterations of enzyme activity and abnormal gene expression in earthworms (Eisenia fetida)., PMID:40345462
Echinococcus multilocularis Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin., PMID:40333123
Engineered Bacterial Biohybrid-Mediated CD47-SIRPα Blockade and HSP90 Inhibition for Enhanced Immuno-Photothermal Therapy., PMID:40331355
AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy., PMID:40320752
DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies., PMID:40319310
Vaccinomics-driven selection and validation of protective salivary antigens from the argasid tick Ornithodoros moubata., PMID:40306020
Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion., PMID:40305178
Effects of anlotinib hydrochloride on the expression of immunogenic cell death-related molecules in Cal27 tongue cancer cells., PMID:40299226
Doxycycline-Induced Apoptosis in Brucella suis S2-Infected HMC3 Cells via Calreticulin Suppression and Activation of the IRE1/Caspase-3 Signaling Pathway., PMID:40290405
Phagocytosis-Activating Nanocomplex Orchestrates Macrophage-Mediated Cancer Immunotherapy., PMID:40289887
The relationship between serum levels of GRP78, GRP94, calnexin, and calreticulin and prognosis in patients with lung cancer., PMID:40289385
Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors., PMID:40287947
Molecular predictors of venous and arterial thrombotic events in patients with myelofibrosis., PMID:40287867
A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner., PMID:40281598
Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer., PMID:40276640
In vitro evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues., PMID:40270993
Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy., PMID:40253314
Nanoarchitectured hyaluronic acid-decorated hierarchical drug-like assemblies as synergistic immune modulators against breast carcinoma., PMID:40250652
Functional characterization of calreticulin in the antiviral response of Litopenaeus vannamei against white spot syndrome virus., PMID:40250553
An oncolytic adenovirus targeting SLAMF7 demonstrates anti-myeloma efficacy., PMID:40247106
LGALS3BP antibody-drug conjugate enhances tumor-infiltrating lymphocytes and synergizes with immunotherapy to restrain neuroblastoma growth., PMID:40217513
Smad7 is a negative regulator of immunogenic cell death in colorectal cancer., PMID:40213961
Regulation of immunogenic cell death and potential applications in cancer therapy., PMID:40207233
Preliminary In silico Analysis of Echinococcus granulosus Calreticulin for Enhanced Vaccine Design against Cystic Echinococcosis., PMID:40195705
PD-L1 targeted antibody-polymer-Epirubicin conjugate prolongs survival in a preclinical murine model of advanced ovarian cancer., PMID:40185333
Complete assignment of 1H and 13C NMR signals of monoglucosylated high-mannose type glycan attached to asparagine., PMID:40168794
A CXCR4-targeted immunomodulatory nanomedicine for photodynamic amplified immune checkpoint blockade therapy against breast cancer., PMID:40154764
Dual blockade of GSTK1 and CD47 improves macrophage-mediated phagocytosis on cancer cells., PMID:40147800
High Expression of Calreticulin Affected the Tumor Microenvironment and Correlated With Worse Prognosis in Patients With Triple-Negative Breast Cancer., PMID:40123257
For research use only. Not for human or drug use.
