Catalog No.
EHG98101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu2-Gln636
Predicted molecular weight
72.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15025
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Naf1, Virion-associated nuclear shuttling protein, VAN, TNFAIP3-interacting protein 1, KIAA0113, HIV-1 Nef-interacting protein, hVAN, A20-binding inhibitor of NF-kappa-B activation 1, Nef-associated factor 1, TNIP1, NAF1, Nip40-1, ABIN-1
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing., PMID:40280976
Conformational Analyses of the AHD1-UBAN Region of TNIP1 Highlight Key Amino Acids for Interaction with Ubiquitin., PMID:40149990
Protocol Development for CRISPR/Cas9 Knockout of the Anti-inflammatory Protein TNIP1 in HaCaT Keratinocytes., PMID:40106146
HSPB1 Orchestrates the Inflammation-Associated Transcriptome Profile of Atherosclerosis in HUVECs., PMID:40018940
A bacterial RING ubiquitin ligase triggering stepwise degradation of BRISC via TOLLIP-mediated selective autophagy manipulates host inflammatory response., PMID:40013521
LncRNA-Gm17586 inhibits S.typhimurium mediated pyroptosis by promoting NLRP3 and Tnip1 binding., PMID:40000898
Targeting TNIP1 as a new therapeutic avenue for major depressive disorder., PMID:39978697
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis., PMID:39827378
Critical Analysis of Cytoplasmic Progression of Inflammatory Signaling Suggests Potential Pharmacologic Targets for Wound Healing and Fibrotic Disorders., PMID:39767629
Complex Genetic Evolution and Treatment Challenges in Myeloid Neoplasms: A Case of Persistent t(2;3)(p15~23;q26)/MECOM Rearrangement, SF3B1 Mutation, and Transient TNIP1::PDGFRB Chimera., PMID:39730178
Genetic causes of primary immunodeficiency in the Jordanian population., PMID:39268404
Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy., PMID:39245437
A TNIP1-driven systemic autoimmune disorder with elevated IgG4., PMID:39060650
Directing risky traffic in B cells with TNIP1., PMID:39060649
Structural basis for TNIP1 binding to FIP200 during mitophagy., PMID:39059492
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing., PMID:38978643
Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3., PMID:38809917
Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence., PMID:38499654
Investigating Protein-Protein Interactions of Autophagy-Involved TNIP1., PMID:38441723
Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence., PMID:37841839
FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m6A methylation of TNIP1., PMID:37781923
TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study., PMID:37751795
Repressive Control of Keratinocyte Cytoplasmic Inflammatory Signaling., PMID:37569318
The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis., PMID:37280058
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1., PMID:36898370
The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR., PMID:36847414
Rare and potentially fatal - Cytogenetically cryptic TNIP1::PDGFRB and PCM1::FGFR1 fusion leading to myeloid/lymphoid neoplasms with eosinophilia in children., PMID:36657267
A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy., PMID:40395303
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1., PMID:36574265
Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities., PMID:36191742
Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms., PMID:36054934
ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis., PMID:36034412
Coilin as a regulator of NF-kB mediated inflammation in preeclampsia., PMID:35762874
A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren's Syndrome., PMID:35749015
Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus., PMID:35475371
The Immunogenetics of Psoriasis., PMID:35286693
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells., PMID:35099607
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage., PMID:35077396
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1., PMID:35042540
CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus., PMID:34580371
Assessment of genetic polymorphisms within nuclear factor-κB signaling pathway genes in rheumatoid arthritis: Evidence for replication and genetic interaction., PMID:34464884
Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-κB 1 (ABIN1) and M1-Linked Ubiquitins., PMID:34161781
A host transcriptomic signature for identification of respiratory viral infections in the community., PMID:34120332
TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder., PMID:33932528
Coordinate regulation of the senescent state by selective autophagy., PMID:33915088
Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach., PMID:33889172
Association of TNIP1 polymorphisms with hepatocellular carcinoma in a Northwest Chinese Han population., PMID:33761643
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer., PMID:33542218
The Anti-Inflammatory Protein TNIP1 Is Intrinsically Disordered with Structural Flexibility Contributed by Its AHD1-UBAN Domain., PMID:33182596
TNIP1/ABIN1 and lupus nephritis: review., PMID:33122334
For research use only. Not for human or drug use.
