Catalog No.
YHB68201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys412
Predicted molecular weight
45.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95503
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Chromobox protein homolog 6, CBX6
Accelerated epigenetic aging in Huntington's disease involves polycomb repressive complex 1., PMID:39934111
Identification of CCR7 and CBX6 as key biomarkers in abdominal aortic aneurysm: Insights from multi-omics data and machine learning analysis., PMID:39602349
CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells., PMID:39179168
Identification of Cbx6 as a potential biomarker in renal ischemia/reperfusion injury., PMID:38452983
The predictive significance of chromobox family members in prostate cancer in humans., PMID:38427207
How CBX proteins regulate normal and leukemic blood cells., PMID:38426219
Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation., PMID:37756159
Bladder cancer course, four genetic high-risk variants, and histopathological findings., PMID:37720238
KMT2A-rearranged sarcoma with unusual fusion gene CBX6::KMT2A::PYGO1., PMID:37713130
SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas., PMID:37504269
An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma., PMID:37430195
Identification of the Prognostic Biomarkers CBX6 and CBX7 in Bladder Cancer., PMID:37189494
Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis., PMID:36970607
Comprehensive Analysis of the Expression and Prognosis of chromobox Family Members in Breast Cancer., PMID:36890004
E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice., PMID:36614300
Chromobox Family Proteins as Putative Biomarkers for Breast Cancer Management: A Preliminary Study Based on Bioinformatics Analysis and qRT-PCR Validation., PMID:36605919
CBX Family Members in Two Major Subtypes of Renal Cell Carcinoma: A Comparative Bioinformatic Analysis., PMID:36292141
Chromobox 7/8 serve as independent indicators for glioblastoma via promoting proliferation and invasion of glioma cells., PMID:36034290
CBXs-related prognostic gene signature correlates with immune microenvironment in gastric cancer., PMID:35969177
Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning., PMID:35836176
Members of the Chromobox Family Have Prognostic Value in Hepatocellular Carcinoma., PMID:35677563
Expression profile and prognostic values of Chromobox family members in human glioblastoma., PMID:35210369
Prognostic Value and Therapeutic Potential of CBX Family Members in Ovarian Cancer., PMID:35155439
Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer., PMID:34880657
Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma., PMID:34790394
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma., PMID:34395271
Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8*., PMID:34174168
CBX6 Promotes HCC Metastasis Via Transcription Factors Snail/Zeb1-Mediated EMT Mechanism., PMID:33311989
Comprehensive analysis of the prognosis for chromobox family in gastric cancer., PMID:33209489
Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer., PMID:33082469
Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion., PMID:33028834
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Chromobox Family Members in Colorectal Cancer., PMID:33014884
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development., PMID:32979540
Diverse CBX family members as potential prognostic biomarkers in non-small-cell lung cancer., PMID:32894652
Mining database for the clinical significance and prognostic value of CBX family in skin cutaneous melanoma., PMID:32860274
Relative mRNA and protein stability of epigenetic regulators in musculoskeletal cell culture models., PMID:32771387
The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model., PMID:32230868
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor., PMID:31755685
Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma., PMID:31211140
CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer., PMID:30655550
Prognostic values of distinct CBX family members in breast cancer., PMID:29190923
The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity., PMID:29089522
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components., PMID:28839133
CBX6 overexpression contributes to tumor progression and is predictive of a poor prognosis in hepatocellular carcinoma., PMID:28122351
Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin., PMID:27723458
Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family., PMID:26985288
Polycomb genes are associated with response to imatinib in chronic myeloid leukemia., PMID:26343356
A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation., PMID:25505127
Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation., PMID:25223915
Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts., PMID:24485159
For research use only. Not for human or drug use.
