Catalog No.
YHA79401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu572
Predicted molecular weight
91.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43823
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AKAP8, A-kinase anchor protein 8, AKAP95, AKAP-8, A-kinase anchor protein 95 kDa, AKAP 95
AKAP95 regulates ubiquitination and degradation of cyclin Ds/Es, influencing the G1/S transition of lung cancer cells., PMID:38923703
AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription., PMID:38711442
SARS-CoV-2 NSP12 utilizes various host splicing factors for replication and splicing regulation., PMID:38235848
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency., PMID:37775760
ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia., PMID:37306722
Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets., PMID:36793283
A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer., PMID:36691407
Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa., PMID:36479111
Genome-Wide Association Studies for Milk Somatic Cell Score in Romanian Dairy Cattle., PMID:34680890
Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation., PMID:33716104
Regulation of tumorigenic splicing by protein condensates with specific biophysical properties., PMID:33235917
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis., PMID:32719551
The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes., PMID:32616651
Cx43 and AKAP95 regulate G1/S conversion by competitively binding to cyclin E1/E2 in lung cancer cells., PMID:32338437
Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer., PMID:32321829
Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix., PMID:32204550
A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition., PMID:32028718
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing., PMID:31980632
Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues., PMID:30990963
AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA., PMID:30982750
PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway., PMID:30809467
miR-21 enhances the protective effect of loperamide on rat cardiomyocytes against hypoxia/reoxygenation, reactive oxygen species production and apoptosis via regulating Akap8 and Bard1 expression., PMID:30680008
Confirmation of BRD4 haploinsufficiency role in Cornelia de Lange-like phenotype and delineation of a 19p13.12p13.11 gene contiguous syndrome., PMID:30302754
A recognizable phenotype related to 19p13.12 microdeletion., PMID:30055032
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations., PMID:29930011
Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells., PMID:29397057
Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo., PMID:29383478
PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein., PMID:29288530
AKAP95-mediated nuclear anchoring of PKA mediates cortisol-induced PTGS2 expression in human amnion fibroblasts., PMID:29162743
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALKATI) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner., PMID:29093346
Epac1, PDE4, and PKC protein expression and their correlation with AKAP95 and Cx43 in esophagus cancer tissues., PMID:28771997
Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues., PMID:28755423
AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint., PMID:28379780
AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors., PMID:27824034
Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells., PMID:26880274
Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase., PMID:26823747
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis., PMID:26683827
Scaffolding during the cell cycle by A-kinase anchoring proteins., PMID:26202611
Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L., PMID:26076356
Synergistic effects of AKAP95, Cyclin D1, Cyclin E1, and Cx43 in the development of rectal cancer., PMID:25973052
High Concentrations of Atmospheric Ammonia Induce Alterations in the Hepatic Proteome of Broilers (Gallus gallus): An iTRAQ-Based Quantitative Proteomic Analysis., PMID:25901992
Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix., PMID:25770215
[Relationship between AKAP95, cyclin E1, cyclin D1, and clinicopathological parameters in lung cancer tissue]., PMID:24370359
Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95., PMID:23995757
DNA methylation, histone modifications and behaviour of AKAP95 during mouse oocyte growth and upon nuclear transfer of foreign chromatin into fully grown prophase oocytes., PMID:23342911
[Expression of A-kinase anchor protein 95, cyclin E2, and connexin 43 in lung cancer tissue, clinical significance of their expression, and their expression correlation]., PMID:23256994
Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels., PMID:23115171
Secretome profile of mouse oocytes after activation using mass spectrum., PMID:22573034
Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function., PMID:22130794
Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages., PMID:21247892
For research use only. Not for human or drug use.
