Catalog No.
YHF59101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn447
Predicted molecular weight
53.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P63151
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PP2A subunit B isoform R2-alpha, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, PP2A subunit B isoform PR55-alpha, PPP2R2A, PP2A subunit B isoform alpha, PP2A subunit B isoform B55-alpha
AKT1E17K-Interacting lncRNA SVIL-AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation., PMID:40135844
Research and progress of microRNA-136 in metastatic tumors., PMID:40104500
miR-455-3p has superior diagnostic potential to PSA in peripheral blood for prostate cancer., PMID:39951446
Characterization of RNF144B and PPP2R2A identified by a novel approach using TCGA data in ovarian cancer., PMID:39948107
Low PPP2R2A expression promotes sensitivity to CHK1 inhibition in high-grade serous ovarian cancer., PMID:39659585
PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis., PMID:39003739
PP2A B55α inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer., PMID:38986733
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs., PMID:38982062
Genetic Rearrangements in Different Salivary Gland Tumors: A Systematic Review., PMID:38966479
The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity., PMID:38889006
Regulatory network analysis based on integrated miRNA-TF reveals key genes in heart failure., PMID:38886500
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells., PMID:38734666
PPP2R2A promotes Hu sheep pituitary cell proliferation and gonadotropin secretion associated with prolificacy., PMID:38677100
Unveiling the mitophagy puzzle in non-alcoholic fatty liver disease (NAFLD): Six hub genes for early diagnosis and immune modulatory roles., PMID:38601640
Molecular mechanism analysis of apoptosis induced by silk fibroin peptides., PMID:38462112
PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation., PMID:38441530
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component., PMID:38365080
Ovarian high-grade serous carcinoma with transitional-like (SET) morphology: a homologous recombination-deficient tumor., PMID:37673346
PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus., PMID:37543698
Protein Phosphatase 2A Regulates Phenotypic and Metabolic Alteration of Microglia Cells in HFD-Associated Vascular Dementia Mice via TNF-α/Arg-1 Axis., PMID:37017907
PPP2R2A promotes testosterone secretion in Hu sheep Leydig cells via activation of the AKT/mTOR signaling pathway., PMID:36883561
VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU., PMID:36781846
Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study., PMID:36681091
A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland., PMID:36625487
Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese., PMID:34898995
p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase., PMID:34731788
PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107., PMID:34661528
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells., PMID:34619436
Exosomal miR-136-5p Derived from Anlotinib-Resistant NSCLC Cells Confers Anlotinib Resistance in Non-Small Cell Lung Cancer Through Targeting PPP2R2A., PMID:34556984
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation., PMID:34144124
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop., PMID:34117214
miR-660 promotes liver cancer cell proliferation by targeting PPP2R2A., PMID:33986848
LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis., PMID:33798913
The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway., PMID:33762326
The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division., PMID:33758202
Mutations in DNA Repair Genes and Clinical Outcomes of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin or Irinotecan-containing Regimens., PMID:33298767
Hsa-MiR-590-3p Promotes the Malignancy Progression of Pancreatic Ductal Carcinoma by Inhibiting the Expression of p27 and PPP2R2A via G1/S Cell Cycle Pathway., PMID:33149617
Lipoblastomas presenting in older children and adults: analysis of 22 cases with identification of novel PLAG1 fusion partners., PMID:33097826
The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis., PMID:32978522
AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells., PMID:32950569
IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation., PMID:32936072
Analysis of CRISPR-Cas9 screens identifies genetic dependencies in melanoma., PMID:32767816
Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development., PMID:32582689
B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?, PMID:32527198
A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors., PMID:32522823
Possible key microRNAs and corresponding molecular mechanisms for atrial fibrillation., PMID:32478689
PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice., PMID:32291379
microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A., PMID:31923339
14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation., PMID:31901078
Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B., PMID:31875526
For research use only. Not for human or drug use.
