Catalog No.
YHK12201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg1627-Ala1761
Predicted molecular weight
41.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H7D0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dedicator of cytokinesis protein 5, DOCK5
Loss of Asxl1 disrupts telencephalic midline integrity through dysregulation of SIX3 target genes., PMID:40393104
Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits., PMID:40038788
The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways., PMID:39741184
Assessing the Mechanism of Rac1b: An All-Atom Simulation Study of the Alternative Spliced Variant of Rac1 Small Rho GTPase., PMID:39632743
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5., PMID:39159301
RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state., PMID:38857861
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape., PMID:38666924
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism., PMID:38161229
PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation., PMID:37434235
Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells., PMID:36551595
Hydroxytyrosol-rich extract from olive juice as an additive in gilthead sea bream juveniles fed a high-fat diet: Regulation of somatic growth., PMID:36277183
Association between polygenetic risk scores related to sarcopenia risk and their interactions with regular exercise in a large cohort of Korean adults., PMID:34560606
Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex., PMID:34290093
ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β., PMID:34216686
Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell., PMID:33577316
The Regulatory Role of Rho GTPases and their Substrates in Osteoclastogenesis., PMID:32981499
Positional cloning and comprehensive mutation analysis of a Japanese family with lithium-responsive bipolar disorder identifies a novel DOCK5 mutation., PMID:32920599
The supression of DOCK family members by their specific inhibitors induces the cell fusion of human trophoblastic cells., PMID:32819582
The regulation of DOCK family proteins on T and B cells., PMID:32542827
Identification of Hub Genes in High-Grade Serous Ovarian Cancer Using Weighted Gene Co-Expression Network Analysis., PMID:32180586
DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling., PMID:31885214
Dock5 is a new regulator of microtubule dynamic instability in osteoclasts., PMID:31461543
MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia., PMID:30668141
Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization., PMID:30661670
Methods to Investigate the Role of Rho GTPases in Osteoclast Function., PMID:30062415
Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant., PMID:29945995
Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells., PMID:29872253
Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections., PMID:29214055
Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule., PMID:29089502
CDC42-related genes are upregulated in helper T cells from obese asthmatic children., PMID:28479334
Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1., PMID:28467910
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion., PMID:27748980
Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases., PMID:27694038
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion., PMID:27669437
Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity., PMID:27505886
Over-expression of EPS15 is a favorable prognostic factor in breast cancer., PMID:26289382
RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch): an experimental model uncoupling the growth hormone and nutritional signals regulating growth., PMID:26228074
[A novel therapeutic approach to fight osteoporosis: disrupt osteoclast activity without affecting bone formation]., PMID:26152154
Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation., PMID:25645278
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation., PMID:25339677
Dock-family exchange factors in cell migration and disease., PMID:25022758
Inhibition of osteoclast bone resorption activity through osteoprotegerin-induced damage of the sealing zone., PMID:25017214
The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth., PMID:24992711
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation., PMID:24913231
The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo., PMID:24365888
p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption., PMID:23526406
Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation., PMID:23362269
Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways., PMID:25033805
Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas., PMID:22837180
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity., PMID:22595969