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Recombinant Human DOCK5 Protein, N-GST

Catalog #:   YHK12201 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q9H7D0
Protein length: Arg1627-Ala1761
Overview

Catalog No.

YHK12201

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Arg1627-Ala1761

Predicted molecular weight

41.79 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9H7D0

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Dedicator of cytokinesis protein 5, DOCK5

Data Image
  • SDS-PAGE
    SDS-PAGE for Recombinant Human DOCK5 protein
References

Loss of Asxl1 disrupts telencephalic midline integrity through dysregulation of SIX3 target genes., PMID:40393104

Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits., PMID:40038788

The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways., PMID:39741184

Assessing the Mechanism of Rac1b: An All-Atom Simulation Study of the Alternative Spliced Variant of Rac1 Small Rho GTPase., PMID:39632743

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5., PMID:39159301

RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state., PMID:38857861

Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape., PMID:38666924

Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism., PMID:38161229

PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation., PMID:37434235

Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells., PMID:36551595

Hydroxytyrosol-rich extract from olive juice as an additive in gilthead sea bream juveniles fed a high-fat diet: Regulation of somatic growth., PMID:36277183

Association between polygenetic risk scores related to sarcopenia risk and their interactions with regular exercise in a large cohort of Korean adults., PMID:34560606

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex., PMID:34290093

ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β., PMID:34216686

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell., PMID:33577316

The Regulatory Role of Rho GTPases and their Substrates in Osteoclastogenesis., PMID:32981499

Positional cloning and comprehensive mutation analysis of a Japanese family with lithium-responsive bipolar disorder identifies a novel DOCK5 mutation., PMID:32920599

The supression of DOCK family members by their specific inhibitors induces the cell fusion of human trophoblastic cells., PMID:32819582

The regulation of DOCK family proteins on T and B cells., PMID:32542827

Identification of Hub Genes in High-Grade Serous Ovarian Cancer Using Weighted Gene Co-Expression Network Analysis., PMID:32180586

DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling., PMID:31885214

Dock5 is a new regulator of microtubule dynamic instability in osteoclasts., PMID:31461543

MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia., PMID:30668141

Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization., PMID:30661670

Methods to Investigate the Role of Rho GTPases in Osteoclast Function., PMID:30062415

Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant., PMID:29945995

Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells., PMID:29872253

Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections., PMID:29214055

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule., PMID:29089502

CDC42-related genes are upregulated in helper T cells from obese asthmatic children., PMID:28479334

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1., PMID:28467910

Tensins are versatile regulators of Rho GTPase signalling and cell adhesion., PMID:27748980

Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases., PMID:27694038

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion., PMID:27669437

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity., PMID:27505886

Over-expression of EPS15 is a favorable prognostic factor in breast cancer., PMID:26289382

RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch): an experimental model uncoupling the growth hormone and nutritional signals regulating growth., PMID:26228074

[A novel therapeutic approach to fight osteoporosis: disrupt osteoclast activity without affecting bone formation]., PMID:26152154

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation., PMID:25645278

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation., PMID:25339677

Dock-family exchange factors in cell migration and disease., PMID:25022758

Inhibition of osteoclast bone resorption activity through osteoprotegerin-induced damage of the sealing zone., PMID:25017214

The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth., PMID:24992711

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation., PMID:24913231

The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo., PMID:24365888

p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption., PMID:23526406

Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation., PMID:23362269

Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways., PMID:25033805

Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas., PMID:22837180

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity., PMID:22595969

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Recombinant Human DOCK5 Protein, N-GST [YHK12201]
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