Catalog No.
YHN42701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu352-Lys832
Predicted molecular weight
20.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92831
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
P300/CBP-associated factor, P/CAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, Spermidine acetyltransferase KAT2B, PCAF, Histone acetyltransferase KAT2B, KAT2B, Histone acetyltransferase PCAF
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression., PMID:40317048
RNA splicing of the STAT3 by PCBP1 promotes vulnerable plaque formation via macrophage-like phenotype modulation of vascular smooth muscle cell., PMID:39938358
Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription., PMID:39901144
PIF/harbinger transposon-derived protein promotes 7SL expression to enhance pathogen resistance., PMID:39885293
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation., PMID:39881208
KAT2B inhibits proliferation and invasion via inactivating TGF-β/Smad3 pathway-medicated autophagy and EMT in epithelial ovarian cancer., PMID:39870682
P3 site-directed mutagenesis: An efficient method based on primer pairs with 3'-overhangs., PMID:39863101
Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia., PMID:39820844
Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown in Drosophila Development., PMID:39728461
Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury., PMID:39721014
PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene., PMID:39497094
Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study., PMID:39466438
K acetyltransferase 2B (KAT2B) variants can be responsible for early onset steroid-resistant nephrotic syndrome., PMID:39366742
Influence of postruminal casein infusion and exogenous glucagon-like peptide 2 administration on the jejunal mucosal transcriptome in cattle., PMID:39146343
KAT2A and KAT2B prevent double-stranded RNA accumulation and interferon signaling to maintain intestinal stem cell renewal., PMID:39110797
The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma., PMID:38820154
The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling., PMID:38641672
Exosomal MALAT1 promotes the proliferation of esophageal squamous cell carcinoma through glyoxalase 1-dependent methylglyoxal removal., PMID:38505306
Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer., PMID:38427147
Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia., PMID:38279051
Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus-A Possible Epigenetic Effect in the Autoimmune Response., PMID:38255677
PSMA7 promotes the malignant proliferation of esophageal cancer., PMID:38173490
Reconstruction of the TGF-β signaling pathway of Fasciola gigantica., PMID:38095703
Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers., PMID:38088751
DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition., PMID:38072145
Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network., PMID:38064496
Enhanced Transcriptional Signature and Expression of Histone-Modifying Enzymes in Salivary Gland Tumors., PMID:37887281
Construction of Prognostic Model and miRNA-mRNA Regulatory Network for Lung Squamous Cell Carcinoma., PMID:37856813
Comprehensive Characterization of HATs and HDACs in Human Cancers Reveals Their Role in Immune Checkpoint Blockade., PMID:37824391
Phosphorylation of KAT-2B by WKS1/Yr36 redirects the lipid flux to jasmonates to enhance resistance against wheat stripe rust., PMID:37666356
Sex-biased genome-editing effects of CRISPR-Cas9 across cancer cells dependent on p53 status., PMID:37636042
Identifying Treatment Resistance Related Pathways by Analyzing Serum Extracellular Vesicles of Patients With Resistant Versus Regressed Retinoblastoma., PMID:37603355
Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B., PMID:37333449
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis., PMID:37117180
Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using next-generation sequencing data and bioinformatics analysis., PMID:37092838
Transcriptomic analysis of esophageal cancer reveals hub genes and networks involved in cancer progression., PMID:37075603
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death., PMID:36894612
N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice., PMID:36864027
p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression., PMID:36750554
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region., PMID:36394358
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression., PMID:36250925
Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis., PMID:36104638
Extracellular vesicle-packaged miR-181c-5p from epithelial ovarian cancer cells promotes M2 polarization of tumor-associated macrophages via the KAT2B/HOXA10 axis., PMID:36027869
N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B., PMID:35848906
Epigenetic modifications control loss of adhesion and aggressiveness of cancer stem cells derived from head and neck squamous cell carcinoma with intrinsic resistance to cisplatin., PMID:35679799
Expression of Protein Acetylation Regulators During Peripheral Nerve Development, Injury, and Regeneration., PMID:35663264
NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury., PMID:35597525
hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B., PMID:35484432
Uncovering Novel Pre-Treatment Molecular Biomarkers for Anti-TNF Therapeutic Response in Patients with Crohn's Disease., PMID:35466218
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion., PMID:35465820
For research use only. Not for human or drug use.
