Anti-Human PIK3CG Monoclonal Antibody (1A128)

Catalog No.

MHE60902

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Immunogen

E. coli - derived recombinant Human PIK3CG (Trp624-Val718).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:2000-1:8000

Target

PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform,PtdIns-3-kinase subunit p110-gamma,PI3Kgamma,p120-PI3K,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,PI3-kinase subunit gamma,PI3K-gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p110gamma,PIK3CG,

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P48736

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

1A128

Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCs., PMID:39382167

PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells., PMID:38961274

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Biomarkers and coptis chinensis activity for rituximab-resistant diffuse large B-cell lymphoma: Combination of bioinformatics analysis, network pharmacology and molecular docking., PMID:38517810

TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation., PMID:38241399

Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens., PMID:36383217

Mesenchymal stem cell transplantation worsens intestinal inflammation and microenvironment in PI3Kγ-knockout mice., PMID:36031460

Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., PMID:36007218

Overcoming resistance to oncolytic virus M1 by targeting PI3K-γ in tumor-associated myeloid cells., PMID:35552024

Exonic variants in multiple myeloma patients associated with relapsed/ refractory and response to bortezomib regimens., PMID:35002457

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases., PMID:34348129

There is no gene for CVID - novel monogenetic causes for primary antibody deficiency., PMID:34153571

Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition., PMID:33785652

PCR Array Technology in Biopsy Samples Identifies Up-Regulated mTOR Pathway Genes as Potential Rejection Biomarkers After Kidney Transplantation., PMID:33681239

B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia., PMID:32640099

Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study., PMID:31964785

Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling., PMID:31753028

(3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one enhanced the therapeutic efficacy of anti-PD1 antibody through inhibiting PI3Kδ/γ., PMID:31691624

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology., PMID:31554793

Intracellular Activation of Complement C3 Leads to PD-L1 Antibody Treatment Resistance by Modulating Tumor-Associated Macrophages., PMID:30514794

Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo., PMID:30391357

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225

Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration., PMID:29479062

Erythropoietin-Producing Hepatoma Receptor Tyrosine Kinase A2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury., PMID:29216437

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ., PMID:29038423

PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression., PMID:28963139

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses., PMID:28003307

Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment., PMID:25201034

Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse., PMID:24935930

Novel PI3Kγ mutation in a 44-year-old man with chronic infections and chronic pelvic pain., PMID:23861857

Loss of phosphoinositide 3-kinase P110γ is protective in the acute phase but detrimental in the resolution phase of hapten-induced colitis., PMID:23282580

p110δ phosphoinositide 3-kinase represses IgE switch by potentiating BCL6 expression., PMID:22422878

Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis., PMID:19907415

PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies., PMID:19876783

PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen., PMID:19494508

Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice., PMID:19232703

CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling., PMID:19060225

Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation., PMID:18786920

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation., PMID:17626838

Angiotensin II-induced delayed stimulation of phospholipase C gamma1 requires activation of both phosphatidylinositol 3-kinase gamma and tyrosine kinase in vascular myocytes., PMID:16989733

Human adenosine A(3) receptor leads to intracellular Ca(2+) mobilization but is insufficient to activate the signaling pathway via phosphoinositide 3-kinase gamma in mice., PMID:16157310

Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate., PMID:15242973

Increased level of neuronal phosphoinositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception., PMID:14980723

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells., PMID:12700661

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy., PMID:12546701

Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes., PMID:11443116

A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells., PMID:11266463

Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway., PMID:11042169

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