Catalog No.
YRC99801
Expression system
E. coli
Species
Rattus norvegicus (Rat)
Protein length
Met28-Glu534
Predicted molecular weight
60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54001
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Prolyl 4-hydroxylase subunit alpha-1, 4-PH alpha-1, 1.14.11.2, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1, P4ha1, P4ha
P4HA1 mediates YAP hydroxylation and accelerates collagen synthesis in temozolomide-resistant glioblastoma., PMID:40484999
Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer., PMID:40463370
Investigating endometrial metabolic characteristics in patients with adenomyosis using gas chromatography/mass spectrometry., PMID:40386953
P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids., PMID:40332386
P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells., PMID:40253309
Discovery of targeting USP10-mediated proline metabolism arrangement to inhibit hepatocellular carcinoma progression., PMID:40158816
Comprehensive analysis of the effects of P4ha1 and P4ha2 deletion on post-translational modifications of fibrillar collagens in mouse skin., PMID:40092628
Protein disulfide isomerase is essential for osteoblast differentiation in mice., PMID:40065084
Glycolysis-related gene signatures and the functional role of P4HA1 in osteosarcoma prognosis., PMID:40023306
Hypoxia-induced ATF3 escalates breast cancer invasion by increasing collagen deposition via P4HA1., PMID:40016181
Ferroptosis-related genes in preeclampsia: integrative bioinformatics analysis, experimental validation and drug prediction., PMID:39984919
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors., PMID:39966387
The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration., PMID:39828692
Hypoxia-induced translation of collagen-modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells., PMID:39710969
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis., PMID:39693409
P4HA1: an important target for treating fibrosis related diseases and cancer., PMID:39568592
IL-10 mediates pleural remodeling in systemic lupus erythematosus., PMID:39563376
Causal relationship between key genes and metabolic dysfunction-associated fatty liver disease risk mediated by immune cells: A Mendelian randomization and mediation analysis., PMID:39228284
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction., PMID:39098433
Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C., PMID:38997072
Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer., PMID:38907027
Comprehensive analysis revealed P4Hs as new biomarkers for prognosis and immunotherapy in head and neck cancer., PMID:38806556
Analyzing molecular signatures in preeclampsia and fetal growth restriction: Identifying key genes, pathways, and therapeutic targets for preterm birth., PMID:38712342
Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices., PMID:38670459
The emerging role of fatty acid binding protein 7 (FABP7) in cancers., PMID:38614160
Unveiling the mitophagy puzzle in non-alcoholic fatty liver disease (NAFLD): Six hub genes for early diagnosis and immune modulatory roles., PMID:38601640
HIF1α/ATF3 partake in PGK1 K191/K192 succinylation by modulating P4HA1/succinate signaling in glioblastoma., PMID:38441561
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma., PMID:38256104
Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1., PMID:38238754
The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome., PMID:38227578
P4HA1 expression and function in esophageal squamous cell carcinoma., PMID:38134053
TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis., PMID:37993861
Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease., PMID:37922570
Primary breast tumor induced extracellular matrix remodeling in premetastatic lungs., PMID:37903851
Evaluation of the Effectiveness of an Innovative Polycomponent Formulation on Adult and Aged Human Dermal Fibroblasts., PMID:37760851
The role of vesicle trafficking genes in osteoblast differentiation and function., PMID:37752218
Identification of metabolic biomarkers associated with nonalcoholic fatty liver disease., PMID:37697333
Multilevel chitosan-gelatin particles loaded with P4HA1 siRNA suppress glioma development., PMID:37667088
Multimerization of HIF enhances transcription of target genes containing the hypoxia ancillary sequence., PMID:37499936
P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma., PMID:37247900
Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation., PMID:37161136
BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis., PMID:37067340
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation., PMID:37029304
Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2., PMID:37003347
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases., PMID:36799463
Cycloheximide promotes type I collagen maturation mainly via collagen prolyl 4-hydroxylase subunit α2., PMID:36789685
P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression., PMID:36734588
P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression., PMID:36702290
In silico Identification of Hypoxic Signature followed by reverse transcription-quantitative PCR Validation in Cancer Cell Lines., PMID:36624663
Comprehensive analysis of roles of atrial-fibrillation-related genes in lung adenocarcinoma using bioinformatic methods., PMID:36542177