Catalog No.
YMN37401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser66-Asp305
Predicted molecular weight
29.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ES89
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EXTR2, Alpha-GalNAcT EXTL2, EXTL2, Exostosin-like 2, EXT-related protein 2, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
[Enriching plasma exosomes for proteomic analysis using a phosphatidylserine-imprinted polymer]., PMID:40331617
Metabolomics- and Proteomics-Based Disease Diagnostic Classifier Model for the Prediction and Diagnosis of Colorectal Carcinoma., PMID:40108892
Prognostic factors and Doxorubicin involved in malignant progression of meningioma., PMID:37024523
Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion., PMID:36181793
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis., PMID:35676258
An Unfolded Protein Response-Related mRNA Signature Predicting the Survival and Therapeutic Effect of Hepatocellular Carcinoma., PMID:35125080
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination., PMID:32703234
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease., PMID:32517548
Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling., PMID:32347583
The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines., PMID:30054430
Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2., PMID:29305908
EXTL2 and EXTL3 inhibition with siRNAs as a promising substrate reduction therapy for Sanfilippo C syndrome., PMID:26347037
Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains., PMID:25829497
Clinical characteristics of hereditary multiple exostoses: a retrospective study of mainland chinese cases in recent 23 years., PMID:24496678
EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis., PMID:24176719
Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes., PMID:23734945
EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner., PMID:23395820
Benign cartilaginous tumors of bone: from morphology to somatic and germ-line genetics., PMID:19700940
Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses., PMID:19690583
Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling., PMID:19011014
Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes., PMID:18463796
Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cells., PMID:17980567
Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation., PMID:17761672
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis., PMID:17237233
Characterization of specific donor binding to alpha1,4-N-acetylhexosaminyltransferase EXTL2 using isothermal titration calorimetry., PMID:17113856
The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I., PMID:16778156
Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase., PMID:15831490
[Biosynthesis of the sulfated glycosaminoglycans in relation to human diseases]., PMID:15524106
Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2., PMID:12659829
EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans., PMID:12565862
Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis., PMID:12562774
Hereditary multiple exostoses and heparan sulfate polymerization., PMID:12417417
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis., PMID:11390981
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate., PMID:11121397
Characterization and genomic localization of the mouse Extl2 gene., PMID:10965119
EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis., PMID:10878610
[Biosynthesis of heparan sulfate and the tumor suppressor EXT gene family]., PMID:10714174
Mutation analysis of hereditary multiple exostoses in the Chinese., PMID:10480354
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate., PMID:10318803
A sugar fix for bone tumours?, PMID:9620760
Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family., PMID:9479495
Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family., PMID:9473480
Identification and characterization of a novel member of the EXT gene family, EXTL2., PMID:9450183
For research use only. Not for human or drug use.
