Catalog No.
YMN41601
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr51-Glu523
Predicted molecular weight
54.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q80W68
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NEPH1, KIRREL1, Kin of IRRE-like protein 1, KIRREL, Nephrin-like protein 1, Kin of irregular chiasm-like protein 1
TAZ downregulated ANXA1 expression to modulate myeloma cell interactions with bone marrow mesenchymal stromal cells., PMID:39032857
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers., PMID:36044856
Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway., PMID:35704761
COX-2-related tumor immune microenvironment in non-small cell lung cancer: a novel signature to predict hot and cold tumor., PMID:35399232
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites., PMID:35177623
Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair., PMID:34391780
Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins., PMID:34288970
Evolution of Fc Receptor-Like Scavenger in Mammals., PMID:33708190
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy., PMID:33351779
Overexpression of kin of IRRE-Like protein 1 (KIRREL) as a prognostic biomarker for breast cancer., PMID:32534710
Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome., PMID:31472902
Disruption of the exocyst induces podocyte loss and dysfunction., PMID:31073028
Overexpression of Kin of IRRE-Like Protein 1 (KIRREL) in Gastric Cancer and Its Clinical Prognostic Significance., PMID:29717104
Identification of novel therapeutic target genes and pathway in pancreatic cancer by integrative analysis., PMID:29049217
Interaction of CD80 with Neph1: a potential mechanism of podocyte injury., PMID:29022109
Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function., PMID:28935902
The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan., PMID:28926934
The long journey through renal filtration: new pieces in the puzzle of slit diaphragm architecture., PMID:28212178
MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes., PMID:27707879
Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1., PMID:27044863
Angiotensin II type 1 receptor blockade ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin., PMID:25298195
Podocyte proteins in congenital and minimal change nephrotic syndrome., PMID:25117488
Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury., PMID:24554715
[New therapeutic insights for chronic kidney disease provided by podocytology]., PMID:24420134
Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum., PMID:23570724
Functional roles for myosin 1c in cellular signaling pathways., PMID:23022959
Signaling from the podocyte intercellular junction to the actin cytoskeleton., PMID:22958485
Functional study of mammalian Neph proteins in Drosophila melanogaster., PMID:22792268
Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS)., PMID:22262837
Comparative analysis of Neph gene expression in mouse and chicken development., PMID:22205279
Early treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephrotic syndrome., PMID:22036940
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis., PMID:21858180
The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins., PMID:21690291
Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane., PMID:21402783
Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats., PMID:21359962
Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin., PMID:21306299
Expression of the IgSF protein Kirre in the rat central nervous system., PMID:21277866
[Human urinary proteome analysis and the open access database of the urinary proteome]., PMID:20560464
Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice., PMID:20375116
Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney., PMID:20067908
Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes., PMID:19794150
Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes., PMID:19515699
Expression of beta-carotene 15,15'- monooxygenase gene and retinol status in rats with puromycin aminonucleoside-induced nephrosis., PMID:19509464
Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression., PMID:19381020
Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1., PMID:18922801
Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis., PMID:18715943
Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity., PMID:18562307
Oxidative stress and cystic fibrosis-related diabetes: a pilot study in children., PMID:18420468
Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2., PMID:18258597
Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy., PMID:17968527
For research use only. Not for human or drug use.
