Catalog No.
YME06701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser34-Asn246
Predicted molecular weight
25.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q792Z0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mesotrypsin, Serine protease 4, PRSS4, Trypsin-3, Trypsin IV, Mesotrypsinogen, TRY4, Brain trypsinogen, Serine protease 3, TRY3, PRSS3, Trypsin III
Genetic Markers of Spina Bifida: Enrichment of Pathogenic Variants and Variants of Uncertain Significance., PMID:40191489
Understanding psoriatic disease at single-cell resolution: an update., PMID:40160177
Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses., PMID:40033250
Cell cycle-based antibody selection for suppressing cancer cell growth., PMID:39953793
Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics., PMID:38878676
Exploring Infantile Epileptic Spasm Syndrome: A Proteomic Analysis of Plasma Using the Data-Independent Acquisition Approach., PMID:38857073
PRSS3/mesotrypsin as a putative regulator of the biophysical characteristics of epidermal keratinocytes in superficial layers., PMID:38811772
The CC2D2B is a novel genetic modifier of the clinical phenotype in patients with hereditary angioedema due to C1 inhibitor deficiency., PMID:38679185
Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens., PMID:37931399
Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomics., PMID:37790472
Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells., PMID:37395651
Rare variant burden analysis from exomes of three consanguineous families reveals LILRB1 and PRSS3 as potential key proteins in inflammatory bowel disease pathogenesis., PMID:37215724
Prognostic assessment capability of a five-gene signature in pancreatic cancer: a machine learning based-study., PMID:36906533
Serine Protease 3 Promotes Progression of Diffuse Large B-Cell Lymphoma and Serves as a Novel Prognostic Predictor., PMID:36618965
The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis., PMID:36517351
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma., PMID:36116415
Construction and evaluation of a prognostic risk model of tumor metastasis-related genes in patients with non-small cell lung cancer., PMID:36056349
Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication., PMID:35896602
Exome Sequencing Reveals Genetic Variability and Identifies Chronic Prognostic Loci in Chinese Sarcoidosis Patients., PMID:35860586
Immunoassay for trypsinogen-4., PMID:35417678
Integrated Genomic Analysis Identifies ANKRD36 Gene as a Novel and Common Biomarker of Disease Progression in Chronic Myeloid Leukemia., PMID:34827175
Axial Impairment Following Deep Brain Stimulation in Parkinson's Disease: A Surgicogenomic Approach., PMID:34602499
KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer., PMID:34333552
In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer., PMID:34195683
High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma., PMID:33758142
Mouse model suggests limited role for human mesotrypsin in pancreatitis., PMID:33526384
Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest., PMID:32967482
Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer., PMID:32800727
Genetic variants entail type 2 diabetes as an innate immune disorder., PMID:32474106
Induction and recovery of CpG site specific methylation changes in human bronchial cells after long-term exposure to carbon nanotubes and asbestos., PMID:32062310
Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation., PMID:32014997
PRSS contributes to cetuximab resistance in colorectal cancer., PMID:31911942
Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression., PMID:31810373
Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation., PMID:31407378
Key genes associated with pancreatic cancer and their association with outcomes: A bioinformatics analysis., PMID:31173193
High-level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer., PMID:30908656
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma., PMID:30755669
Serum Serine Peptidase Inhibitor Kazal-Type 1, Trypsinogens 1 to 3, and Complex of Trypsin 2 and α1-Antitrypsin in the Diagnosis of Severe Acute Pancreatitis., PMID:30747826
Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin., PMID:30700553
Single-nucleotide and copy-number variance related to severity of hypospadias., PMID:30078147
Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines., PMID:29629340
Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma., PMID:28844099
Small molecule inhibitors of mesotrypsin from a structure-based docking screen., PMID:28463992
PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast., PMID:28423522
Epithelial expression and function of trypsin-3 in irritable bowel syndrome., PMID:28096305
Retraction Note to: Clinical significance and expression of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer., PMID:27817076
PO-44 - Tissue factor pathway inhibitor-2 (TFPI-2) is cleaved by PRSS3: implication for tumor endothelial cells migration., PMID:27161730
Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy., PMID:26957636
Clinical significance and expression of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer., PMID:26662304
Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2., PMID:26318044
For research use only. Not for human or drug use.
