Catalog No.
YMN37801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser26-Ala204
Predicted molecular weight
21.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P83714
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cardiotrophin-2, CT-2, Neuropoietin, Np, Ctf2, Gm494
GW501516-Mediated Targeting of Tetraspanin 15 Regulates ADAM10-Dependent N-Cadherin Cleavage in Invasive Bladder Cancer Cells., PMID:38667323
N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of β-catenin translocation., PMID:36939278
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10., PMID:36631513
Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression., PMID:35008415
Enhancement of E-cadherin expression and processing and driving of cancer cell metastasis by ARID1A deficiency., PMID:34290402
PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival., PMID:32541930
The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis., PMID:29428965
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome., PMID:28735867
Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation., PMID:27856599
Interplay of N-Cadherin and matrix metalloproteinase 9 enhances human nasopharyngeal carcinoma cell invasion., PMID:27737648
Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition., PMID:26746659
Cytoskeletal changes induced by allosteric modulators of calcium-sensing receptor in esophageal epithelial cells., PMID:26603452
Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells., PMID:23876460
Lipolytic system of the tomato pathogen Fusarium oxysporum f. sp. lycopersici., PMID:23718123
The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells., PMID:22665490
Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7., PMID:22638108
Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling., PMID:21852538
Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein., PMID:21746865
Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells., PMID:20471383
Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors., PMID:19661068
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus., PMID:18356166
Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor., PMID:17257767
Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination., PMID:17185320
Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin., PMID:16707106
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1., PMID:16687212
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling., PMID:16511561
The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors., PMID:16417575
Cisplatin resistance and transcription factors., PMID:15720258
Production and purification of monoclonal and polyclonal antibodies against cholera toxin., PMID:15319074
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations., PMID:13678586
Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression., PMID:12534345
NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cells., PMID:11463853
Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain., PMID:8171010
Identification of regulatory elements in the cutinase promoter from Fusarium solani f. sp. pisi (Nectria haematococca)., PMID:8132657
Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16., PMID:8392590
For research use only. Not for human or drug use.
