Catalog No.
YHN36101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp198
Predicted molecular weight
24.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6B6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GTP-binding protein SAR1b, SAR1B, SARB, GTP-binding protein B, SARA2, GTBPB
Fenofibrate Treatment Inhibits Very-Low-Density Lipoprotein Transport Vesicle Formation by Reducing Sar1b Protein Expression., PMID:40429862
Functional diversification of Sec13 isoforms for storage protein trafficking in rice endosperm cells., PMID:39351808
Study on the mechanism of SAR1B in sodium acetate promoting milk fat synthesis., PMID:39316237
Unraveling Chylomicron Retention Disease Enhances Insight into SAR1B GTPase Functions and Mechanisms of Actions, While Shedding Light of Intracellular Chylomicron Trafficking., PMID:39062121
Arabidopsis Sar1b is critical for pollen tube growth., PMID:38809410
[Chylomicron retention disease caused by SAR1B gene variations in 2 cases and literatures review]., PMID:38763880
Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo., PMID:38687799
Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo., PMID:38463989
Analysis of the Mouse Hepatic Peroxisome Proteome-Identification of Novel Protein Constituents Using a Semi-Quantitative SWATH-MS Approach., PMID:38247867
Carotenoids in familial hypobetalipoproteinemia disorders: Malabsorption in Caco2 cell models and severe deficiency in patients., PMID:37989694
High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism., PMID:37558128
Arabidopsis Sar1 isoforms play redundant roles in female gametophytic development., PMID:37535249
Validation of Knock-Out Caco-2 TC7 Cells as Models of Enterocytes of Patients with Familial Genetic Hypobetalipoproteinemias., PMID:36771214
The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing., PMID:36467401
The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1., PMID:36369712
Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis., PMID:36252341
Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis., PMID:36096639
Expression Regulation Mechanisms of Sea Urchin (Strongylocentrotus intermedius) Under the High Temperature: New Evidence for the miRNA-mRNA Interaction Involvement., PMID:35846155
Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells., PMID:35691593
Comparison of two polygenic risk scores to identify non-monogenic primary hypocholesterolemias in a large cohort of Italian hypocholesterolemic subjects., PMID:35589500
FYVE2, a phosphatidylinositol 3-phosphate effector, interacts with the COPII machinery to control autophagosome formation in Arabidopsis., PMID:34718777
Chylomicron retention disease caused by a new pathogenic variant in sar1b protein: a rare case report from Syria., PMID:34629076
SAR1B senses leucine levels to regulate mTORC1 signalling., PMID:34290409
Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease., PMID:33964306
Functional characterization of Copy Number Variations regions in Djallonké sheep., PMID:33682236
ApoB SURFs a Ride from the ER to the Golgi., PMID:33535097
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans., PMID:33186557
Inhibition of Sar1b, the Gene Implicated in Chylomicron Retention Disease, Impairs Migration and Morphogenesis of Developing Cortical Neurons., PMID:33002559
Knockdown of SAR1B suppresses proliferation and induces apoptosis of RKO colorectal cancer cells., PMID:32952655
Rapeseed Lecithin Increases Lymphatic Lipid Output and α-Linolenic Acid Bioavailability in Rats., PMID:32937654
Time-Dependent miRNA Profile during Septic Acute Kidney Injury in Mice., PMID:32727087
Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly., PMID:32358066
COPII Components Sar1b and Sar1c Play Distinct Yet Interchangeable Roles in Pollen Development., PMID:32327549
Chylomicron Retention Disease in A Male Infant: A Rare Case from Pakistan., PMID:32257723
SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation., PMID:31409740
Novel mutations of SAR1B gene in four children with chylomicron retention disease., PMID:31253576
Targeted Quantitative Proteomic Approach for Probing Altered Protein Expression of Small GTPases Associated with Colorectal Cancer Metastasis., PMID:30943010
Molecular analysis of APOB, SAR1B, ANGPTL3, and MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients., PMID:30782561
Chylomicron retention disease: genetics, biochemistry, and clinical spectrum., PMID:30640893
Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5., PMID:30251687
A simple supported tubulated bilayer system for evaluating protein-mediated membrane remodeling., PMID:30012406
Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition., PMID:29729190
Dimeric sorting code for concentrative cargo selection by the COPII coat., PMID:29555761
Complex genetic architecture in severe hypobetalipoproteinemia., PMID:29540175
Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis., PMID:29074889
Understanding Chylomicron Retention Disease Through Sar1b Gtpase Gene Disruption: Insight From Cell Culture., PMID:28982670
Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH)., PMID:28062946
GOLGI TRANSPORT 1B Regulates Protein Export from the Endoplasmic Reticulum in Rice Endosperm Cells., PMID:27803308
Understanding Plastid Vesicle Transport - Could it Provide Benefit for Human Medicine?, PMID:27599970
Chylomicron retention disease: A rare cause of chronic diarrhea., PMID:27266643
For research use only. Not for human or drug use.
