Catalog No.
YHN35901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg210
Predicted molecular weight
26.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2L1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RRP44, Ribosomal RNA-processing protein 44, DIS3, KIAA1008, Exosome complex exonuclease RRP44, Protein DIS3 homolog
EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA., PMID:40501579
Dis3l2 is essential for neural crest survival by modulating Akt signaling., PMID:40500755
Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach., PMID:40399278
The ER-PM interaction is essential for cytokinesis and recruits the actin cytoskeleton through the SCAR/WAVE complex., PMID:39913210
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation., PMID:39800708
A Comparative Overview of the Role of Human Ribonucleases in Nonsense-Mediated mRNA Decay., PMID:39457432
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer., PMID:39408874
Functional characterization of human recessive DIS3 variants in premature ovarian insufficiency†., PMID:39400047
ZC3H4/Restrictor Exerts a Stranglehold on Pervasive Transcription., PMID:39002716
DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice., PMID:38953252
Engineering stringent genetic biocontainment of yeast with a protein stability switch., PMID:38316765
Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export., PMID:38306394
Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma., PMID:38252427
Copy number variants landscape of multiple cancers and clinical applications based on NGS gene panel., PMID:37967237
Reduced female fertility due to sequestration of RNA Pol II by pervasive transcription in exosome RNase-depleted oocytes., PMID:37831603
Effect of MAPK activation via mutations in NRAS, KRAS and BRAF on clinical outcome in newly diagnosed multiple myeloma., PMID:37452600
DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification., PMID:37439377
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells., PMID:37315586
A genomic score to predict local control among patients with brain metastases managed with radiation., PMID:37260393
Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception., PMID:37192170
Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility., PMID:37172450
DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis., PMID:36869713
In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae., PMID:36861343
DIS3: The Enigmatic Gene in Multiple Myeloma., PMID:36835493
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation., PMID:36724075
MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing., PMID:36403484
Advances in the molecular characterization of multiple myeloma and mechanism of therapeutic resistance., PMID:36387095
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism., PMID:36215697
TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review., PMID:36181538
Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias., PMID:36138464
Genome-Wide Screening and Stability Verification of the Robust Internal Control Genes for RT-qPCR in Filamentous Fungi., PMID:36135677
Molecular fingerprints of polar narcotic chemicals based on heterozygous essential gene knockout library in Saccharomyces cerevisiae., PMID:36087727
MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus., PMID:35902094
Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population., PMID:35770320
Defining pervasive transcription units using chromatin RNA-sequencing data., PMID:35693207
RNA exosome drives early B cell development via noncoding RNA processing mechanisms., PMID:35658015
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study., PMID:35617957
MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3., PMID:35394705
How hydrolytic exoribonucleases impact human disease: Two sides of the same story., PMID:35247037
piRNAs Interact with Cold-Shock Domain-Containing RNA Binding Proteins and Regulate Neuronal Gene Expression During Differentiation., PMID:34982407
Reverse Genetic Screen for Deleterious Recessive Variants in the Local Simmental Cattle Population of Switzerland., PMID:34944310
Reproducible and efficient new method of RNA 3'-end labelling by CutA nucleotidyltransferase-mediated CC-tailing., PMID:34766865
Epidemiology, genetics and treatment of multiple myeloma and precursor diseases., PMID:34398972
Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders., PMID:34343137
Interplay of the RNA Exosome Complex and RNA-Binding Protein Ssd1 in Maintaining Cell Wall Stability in Yeast., PMID:34259554
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis., PMID:34059908
DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome., PMID:33951891
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells., PMID:33526923
Yeast RNA exosome activity is necessary for maintaining cell wall stability through proper protein glycosylation., PMID:33439673
For research use only. Not for human or drug use.
