Catalog No.
YHN35601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr354-Gly565
Predicted molecular weight
27.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULX6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Helicase A-binding protein 95, AKAP8L, Neighbor of AKAP95, Neighbor of A-kinase-anchoring protein 95, Homologous to AKAP95 protein, A-kinase anchor protein 8-like, AKAP8-like protein, HA95, NAKAP, NAKAP95, HAP95
Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering., PMID:39033121
Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer., PMID:37683130
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders., PMID:36950384
Mutations in SARS-CoV-2 structural proteins: a global analysis., PMID:36528612
AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA., PMID:36522343
Novel prognostic model predicts overall survival in colon cancer based on RNA splicing regulation gene expression., PMID:35792657
High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma., PMID:35189899
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells., PMID:32457162
A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth., PMID:32312749
Confirmation of BRD4 haploinsufficiency role in Cornelia de Lange-like phenotype and delineation of a 19p13.12p13.11 gene contiguous syndrome., PMID:30302754
A recognizable phenotype related to 19p13.12 microdeletion., PMID:30055032
SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data., PMID:29596423
PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein., PMID:29288530
Comparison of 2, 5, and 20 % O2 on the development of post-thaw human embryos., PMID:27007876
Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L., PMID:26076356
The role of A-kinase anchoring protein 95-like protein in annealing of tRNALys3 to HIV-1 RNA., PMID:25034436
High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease., PMID:24011924
Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways., PMID:23633038
A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95., PMID:18313049
In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling., PMID:12950172
Architectural defects in pronuclei of mouse nuclear transplant embryos., PMID:12890757
Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication., PMID:12740381
Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme., PMID:12727975
HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication., PMID:12538639
AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex., PMID:12414807
Differential regulation of maternal and paternal chromosome condensation in mitotic zygotes., PMID:12082153
Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting., PMID:11964380
Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins., PMID:11884601
Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis., PMID:11591814
Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses., PMID:11402034
A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase., PMID:11279182
EBNA-LP associates with cellular proteins including DNA-PK and HA95., PMID:11160753
HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics., PMID:11034899
A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract., PMID:10791967
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding., PMID:10764601
Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95., PMID:10761695
A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element., PMID:10748171
cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region., PMID:10697960
The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis., PMID:10601332
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95., PMID:9473338
Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5., PMID:7929081
For research use only. Not for human or drug use.
