Catalog No.
YHN34501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala432-Phe540
Predicted molecular weight
15.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZN8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CCR4-associated factor 2, CDC36, NOT2, CNOT2, CCR4-NOT transcription complex subunit 2
RNA-Binding Motif Protein 22 Induces Apoptosis via c-Myc Pathway in Colon Cancer Cells., PMID:40142004
Acetylcorynoline Induces Apoptosis and G2/M Phase Arrest through the c-Myc Signaling Pathway in Colon Cancer Cells., PMID:38139419
A novel proteomic-based model for predicting colorectal cancer with Schistosoma japonicum co-infection by integrated bioinformatics analysis and machine learning., PMID:37904220
Momordicae Semen inhibits migration and induces apoptotic cell death by regulating c-Myc and CNOT2 in human pancreatic cancer cells., PMID:37550432
Euonymus sachalinensis Induces Apoptosis by Inhibiting the Expression of c-Myc in Colon Cancer Cells., PMID:37110707
Prevalence, causes and impact of TP53-loss phenocopying events in human tumors., PMID:37095494
Clinical characterization of a patient with CNOT2 haploinsufficiency caused by a de novo partial deletion., PMID:36728774
Ophiopogonin D increase apoptosis by activating p53 via ribosomal protein L5 and L11 and inhibiting the expression of c-Myc via CNOT2., PMID:36569330
The Antitumor Effect of Timosaponin A3 through c-Myc Inhibition in Colorectal Cancer Cells and Combined Treatment Effect with 5-FU or Doxorubicin., PMID:36233202
Delineation of the clinical profile of CNOT2 haploinsufficiency and overview of the IDNADFS phenotype., PMID:36224108
CCR4-NOT Complex 2-A Cofactor in Host Cell for Porcine Epidemic Diarrhea Virus Infection., PMID:36140672
CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells., PMID:36111570
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2., PMID:35129087
Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition., PMID:34698000
Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53., PMID:34680125
Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors., PMID:34176176
CNOT2 haploinsufficiency in a 40-year-old man with intellectual disability, autism, and seizures., PMID:34018673
Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor., PMID:33178760
Silencing of CCR4-NOT complex subunits affects heart structure and function., PMID:32471864
Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2., PMID:32316188
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors., PMID:31967407
CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway., PMID:31894259
CNOT2 Is Critically Involved in Atorvastatin Induced Apoptotic and Autophagic Cell Death in Non-Small Cell Lung Cancers., PMID:31574980
CNOT2 haploinsufficiency causes a neurodevelopmental disorder with characteristic facial features., PMID:31512373
Transcriptome profiling of longissimus thoracis muscles identifies highly connected differentially expressed genes in meat type sheep of India., PMID:31170190
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway., PMID:31155293
A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome., PMID:31145527
CNOT2 as the critical gene for phenotypes of 12q15 microdeletion syndrome., PMID:30768759
The circular RNome of primary breast cancer., PMID:30692147
CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells., PMID:29024811
RNA sequencing of esophageal adenocarcinomas identifies novel fusion transcripts, including NPC1-MELK, arising from a complex chromosomal rearrangement., PMID:28640357
The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription., PMID:28615693
CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy., PMID:28537904
Reassessment of the 12q15 deletion syndrome critical region., PMID:28159701
The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression., PMID:27273514
HIPK family kinases bind and regulate the function of the CCR4-NOT complex., PMID:27122605
The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells., PMID:27037025
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7., PMID:26807845
CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARx03B3;, CEBPα and Inhibition of P-GSK3α/β and β-Catenin., PMID:26584287
Cross-platform assessment of genomic imbalance confirms the clinical relevance of genomic complexity and reveals loci with potential pathogenic roles in diffuse large B-cell lymphoma., PMID:26294112
An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease., PMID:24322557
Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells., PMID:24200330
Structure and assembly of the NOT module of the human CCR4-NOT complex., PMID:24121232
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation., PMID:22367759
Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development., PMID:21741365
CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death., PMID:21299754
Human Ccr4-Not complexes contain variable deadenylase subunits., PMID:19558367
Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line., PMID:18160213
Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex., PMID:16712523
The cyclin-dependent kinase 11 interacts with NOT2., PMID:16039607
For research use only. Not for human or drug use.
