Catalog No.
YHN34301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly32-Val150
Predicted molecular weight
40.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NXI6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNF186, RING finger protein 186, E3 ubiquitin-protein ligase RNF186
RNF186 gene variant and zonulin levels in inflammatory bowel disease: A pilot study., PMID:40328563
Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis., PMID:40230421
Systematic pan-cancer analysis of RNF186 with potential implications in progression and prognosis in human cancer., PMID:38160786
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease., PMID:38158076
HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells., PMID:37137894
HGF Secreted by Menstrual Blood-Derived Endometrial Stem Cells Ameliorates Non-Alcoholic Fatty Liver Disease Through Downregulation of Hepatic Rnf186., PMID:36573461
RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells., PMID:36130827
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression., PMID:36085200
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response., PMID:34623328
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes., PMID:34353900
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis., PMID:33280498
The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB., PMID:32882406
The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function., PMID:32486221
The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing., PMID:31586034
Rare and common variant discovery in complex disease: the IBD case study., PMID:31363759
RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes., PMID:30223017
The genetic background of inflammatory bowel disease: from correlation to causality., PMID:27785786
Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis., PMID:27619887
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis., PMID:27503255
Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186., PMID:27381925
Rare mutations associating with serum creatinine and chronic kidney disease., PMID:25082825
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis., PMID:24068945
A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1., PMID:23896122
For research use only. Not for human or drug use.
