Catalog No.
YHJ68302
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly307-Lys379
Predicted molecular weight
36.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NX58
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell growth-regulating nucleolar protein, LYAR
Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling., PMID:40408479
The role of CD101 and Tim3 in the immune microenvironment of gastric cancer and their potential as prognostic biomarkers., PMID:39700955
Exploring heparin's protective mechanism against AGEs induced endothelial injury., PMID:39493878
The Prospective role of lapatinib as an adjuvant therapy in prevalent cancers: Insights from in silico analysis targeting EGFR and HER2., PMID:39369912
A Comprehensive Analysis of LYAR in Colorectal Cancer: Prognostic Marker and Therapeutic Target., PMID:39159060
Higher expression of TSR2 aggravating hypertension via the PPAR signaling pathway., PMID:38814181
Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical Applications., PMID:38673849
RRP9 and DDX21 as new biomarkers of colorectal cancer., PMID:37904456
The fraction of life years lost after diagnosis (FLYLAD): a person-centred measure of cancer burden., PMID:37704992
Identification of diagnostic biomarkers via weighted correlation network analysis in colorectal cancer using a system biology approach., PMID:37604903
The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers., PMID:36614221
Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses., PMID:36070690
Identification of Important Modules and Hub Gene in Chronic Kidney Disease Based on WGCNA., PMID:35571562
LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism., PMID:35069968
LYAR promotes the proliferation of non-small cell lung cancer and is associated with poor prognosis., PMID:34890041
Analysis of the role of Ly-1 antibody reactive in different cancer types., PMID:34696677
HMGB1 Protein Interactions in Prostate and Ovary Cancer Models Reveal Links to RNA Processing and Ribosome Biogenesis through NuRD, THOC and Septin Complexes., PMID:34572914
LINC00355 promoted the progression of lung squamous cell carcinoma through regulating the miR-466/LYAR axis., PMID:33111744
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood., PMID:32351504
LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA., PMID:31504794
LYAR Suppresses Beta Interferon Induction by Targeting Phosphorylated Interferon Regulatory Factor 3., PMID:31413131
Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia., PMID:31300855
Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation., PMID:31076509
Hematopoietic tissue of Macrobrachium rosenbergii plays dual roles as a source of hemocyte hematopoiesis and as a defensive mechanism against Macrobrachium rosenbergii nodavirus infection., PMID:30553890
The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus., PMID:30209172
Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer., PMID:29722257
Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation., PMID:29505757
Up-regulation of LYAR blocks Myc-induced cell death., PMID:28934009
An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production., PMID:28851297
Upregulation of LYAR induces neuroblastoma cell proliferation and survival., PMID:28686580
A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression., PMID:28669403
Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β0-Thalassemia Families with High Fetal Hemoglobin Levels., PMID:26897028
LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression., PMID:26413750
Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1., PMID:26203195
Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis., PMID:25735755
Human fetal globin gene expression is regulated by LYAR., PMID:25092918
Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells., PMID:24990247
Early targets of miR-34a in neuroblastoma., PMID:24912852
Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA., PMID:24495227
Expression and function of the testis-predominant protein LYAR in mice., PMID:23212345
Mutations in Lyar and p53 are synergistically lethal in female mice., PMID:22815056
Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells., PMID:19489080
Elimination of the differential chemoresistance between the murine B-cell lymphoma LY-ar and LY-as cell lines after arsenic (As2O3) exposure via the overexpression of gsto1 (p28)., PMID:15761769
The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis., PMID:12801933
NF-kappaB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene., PMID:11567031
Paclitaxel restores radiation-induced apoptosis in a bcl-2-expressing, radiation-resistant lymphoma cell line., PMID:11240255
Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis., PMID:10716996
Bcl-2 expression correlates with apoptosis induction but not tumor growth delay in transplantable murine lymphomas treated with different chemotherapy drugs., PMID:10501909
Analysis of redox regulation of cytochrome c-induced apoptosis in a cell-free system., PMID:10453079
ASTRO research fellowship: the role of BCL-2 and glutathione in an antioxidant pathway to prevent radiation-induced apoptosis., PMID:9747837
For research use only. Not for human or drug use.
