Catalog No.
YHN33901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr386-Cys681
Predicted molecular weight
36.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NQU5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PAK-6, PAK5, PAK-5, PAK6, p21-activated kinase 6, Serine/threonine-protein kinase PAK 6
Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia., PMID:40234614
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14., PMID:40194572
miR-3191 promotes the proliferation and metastasis of hepatocellular carcinoma via regulating PAK6., PMID:39696440
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner., PMID:39419978
Ethanol extract of Vanilla planifolia stems reduces PAK6 expression and induces cell death in glioblastoma cells., PMID:39233332
PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells., PMID:38763182
Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson's Disease., PMID:38640169
Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes., PMID:38527292
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation., PMID:38169846
FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways., PMID:38055646
Ephexin3/ARHGEF5 Together with Cell Migration Signaling Partners within the Tumor Microenvironment Define Prognostic Transcriptional Signatures in Multiple Cancer Types., PMID:38003617
A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province., PMID:37796667
Urinary exosome proteins PAK6 and EGFR as noninvasive diagnostic biomarkers of diabetic nephropathy., PMID:37789280
The coexistence of aflatoxin M1 and ochratoxin A induced intestinal barrier disruption via the regulation of key differentially expressed microRNAs and long non-coding RNAs in BALB/c mice., PMID:37688864
TWN-RENCOD: A novel method for protein binding site comparison., PMID:36618985
The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration., PMID:36423859
SLC6A14 facilitates epithelial cell ferroptosis via the C/EBPβ-PAK6 axis in ulcerative colitis., PMID:36272033
SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells., PMID:36213507
Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells., PMID:35969127
PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer., PMID:35902562
Molecular Epidemiology of Cryptosporidium parvum and Giardia lamblia in Different Water Bodies, Soil, and Vegetables in Pakistan., PMID:35861848
Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis., PMID:35306484
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis., PMID:35255921
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation., PMID:35016853
Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets., PMID:34321157
Gene Expression Profile of the Human Colorectal Carcinoma LoVo Cells Treated With Sporamin and Thapsigargin., PMID:34113558
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung., PMID:33915162
Equine early pregnancy endocrine profiles and ipsilateral endometrial immune cell, gene expression and protein localisation response., PMID:33752795
Comprehensive transcriptome analysis of hypothalamus reveals genes associated with disorders of sex development in pigs., PMID:33746111
Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis., PMID:33145269
p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5., PMID:33098954
PAK6 promotes cervical cancer progression through activation of the Wnt/β-catenin signaling pathway., PMID:32782556
miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats., PMID:32679145
LncRNA DANCR-miR-758-3p-PAX6 Molecular Network Regulates Apoptosis and Autophagy of Breast Cancer Cells., PMID:32581581
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML., PMID:32270193
Mitochondrial PAK6 inhibits prostate cancer cell apoptosis via the PAK6-SIRT4-ANT2 complex., PMID:32194820
Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation., PMID:32005669
Systemic analysis of the expression and prognostic significance of PAKs in breast cancer., PMID:31987914
The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences., PMID:31391252
Detection of the steroid receptor interacting protein, PAK6, in a neuronal cell line., PMID:30923762
Bioinformatic analysis of four miRNAs relevant to metastasis-regulated processes in endometrial carcinoma., PMID:30122983
[Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase]., PMID:30113035
DNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications., PMID:29912614
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2., PMID:29311810
Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis., PMID:29307797
The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex., PMID:29117290
The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis., PMID:28935395
Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis., PMID:28816646
Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development., PMID:28765528
PAK6-Associated Support Vector Machine Classifier: A New Way to Evaluate Response and Survival of Gastric Cancer Treated by 5-FU/Oxaliplatin Chemotherapy., PMID:28688823
For research use only. Not for human or drug use.
