Catalog No.
YHN33801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg188-Ala365
Predicted molecular weight
23.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NQ90
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C12orf3, ANO2, Transmembrane protein 16B, TMEM16B, Anoctamin-2
The Role of the Ca2+-activated Cl- Conductance in the Membrane Potential and Light Response of Mouse Rods., PMID:40280711
Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls., PMID:40063790
Bee venom peptide Anoplin conjugates as antibacterial agents for both Gram-positive and Gram-negative bacteria., PMID:39889890
Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects., PMID:39860130
In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis., PMID:39742283
Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen., PMID:39514389
Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis., PMID:39257578
The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons., PMID:39167717
ANO2 Genetic Variants and Anti-VEGF Treatment Response in Neovascular AMD: A Pharmacogenetic Substudy of VIEW 1 and VIEW 2., PMID:38980270
Anticancer Effect of Hemin through ANO1 Inhibition in Human Prostate Cancer Cells., PMID:38892219
Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells., PMID:38825009
The physiological roles of anoctamin2/TMEM16B and anoctamin1/TMEM16A in chemical senses., PMID:38677213
Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage., PMID:37802637
The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival., PMID:37692493
Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation., PMID:37403222
Paradoxical electro-olfactogram responses in TMEM16B knock-out mice., PMID:36744918
VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1., PMID:35563558
Influence of temperature during incubation on the mRNA levels of temperature sensitive ion channels in the brain of broiler chicken embryos., PMID:35337975
Chloride channels with ClC-1-like properties differentially regulate the excitability of dopamine receptor D1- and D2-expressing striatal medium spiny neurons., PMID:35080921
Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels., PMID:34488544
Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy., PMID:34450215
AB569, a Novel, Topical Bactericidal Gel Formulation, Kills Pseudomonas aeruginosa and Promotes Wound Healing in a Murine Model of Burn Wound Infection., PMID:34424744
Honokiol inhibits proliferation of colorectal cancer cells by targeting anoctamin 1/TMEM16A Ca2+ -activated Cl- channels., PMID:34192810
Genome-Wide Identification of Candidate Genes for Milk Production Traits in Korean Holstein Cattle., PMID:34068321
AB569, a non-toxic combination of acidified nitrite and EDTA, is effective at killing the notorious Iraq/Afghanistan combat wound pathogens, multi-drug resistant Acinetobacter baumannii and Acinetobacter spp., PMID:33657146
Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells., PMID:33651839
[Calcium-activated chloride channels: structure, properties, role in physiological and pathological processes]., PMID:33645519
Combining EXAFS and Computer Simulations to Refine the Structural Description of Actinyls in Water., PMID:33187172
Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers., PMID:32906067
A Novel Bactericidal Drug Effective Against Gram-Positive and Gram-Negative Pathogenic Bacteria: Easy as AB569., PMID:32721230
Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors., PMID:32592976
Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling., PMID:32517157
AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria., PMID:32071223
EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca2+ and Voltage., PMID:31902154
Contributions of glutamate transporters and Ca2+-activated Cl- currents to feedback from horizontal cells to cone photoreceptors., PMID:31628905
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala., PMID:31482844
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk., PMID:31375628
Autoantibodies in Pandemrix®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test., PMID:31328572
TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice., PMID:31320449
The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection., PMID:31158231
Estrogen receptor alpha activates MAPK signaling pathway to promote the development of endometrial cancer., PMID:31140648
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes., PMID:31057674
TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons., PMID:30843875
Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors., PMID:30347323
Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons., PMID:30006552
[Screening of familial primary biliary cholangitis and research on low-frequency mutations by whole-exome sequencing]., PMID:29996209
Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression., PMID:29769308
Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons., PMID:29735665
Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal., PMID:29604966
TMEM16A inhibition impedes capacitation and acquisition of hyperactivated motility in guinea pig sperm., PMID:29600587
For research use only. Not for human or drug use.
