Catalog No.
YHN33001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr426-Ala646
Predicted molecular weight
27.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H4B4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FGF-inducible kinase, FNK, PLK-3, Serine/threonine-protein kinase PLK3, Cytokine-inducible serine/threonine-protein kinase, PLK3, PRK, CNK, Polo-like kinase 3, Proliferation-related kinase
TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling., PMID:40350054
Pan-cancer genetic profiles of mitotic DNA integrity checkpoint protein kinases., PMID:40095483
IGF2BP3 prefers to regulate alternative splicing of genes associated with the progression of gastric cancer in AGS cells., PMID:39998701
Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma., PMID:39866232
PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress., PMID:39837970
Pachytene piRNAs control discrete meiotic events during spermatogenesis and restrict gene expression in space and time., PMID:39356768
Transcriptome analysis reveals that defects in cell cycle regulation contribute to preimplantation embryo arrest., PMID:39326642
SLAMF1 as a novel molecule mediating the causal association between rheumatoid arthritis and interstitial lung disease: A Mendelian randomization study combined with transcriptomics and in vivo validation., PMID:39260308
High PLK3 levels are linked with less tumor invasion, lower FIGO stage and better prognosis of endometrial cancer., PMID:39082977
Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3., PMID:38987177
Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes., PMID:38932912
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy., PMID:38906226
An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts., PMID:38630692
PLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer., PMID:38629862
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer., PMID:38605037
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling., PMID:38520019
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription., PMID:38169509
PLK3 facilitates replication of swine influenza virus by phosphorylating viral NP protein., PMID:37874309
TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3., PMID:37873730
PLK3 promotes the proneural-mesenchymal transition in glioblastoma via transcriptional regulation of C5AR1., PMID:37568042
Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate., PMID:37549410
Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic β cells., PMID:37134105
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells., PMID:37049713
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells., PMID:36865333
Comprehensive analysis of PLKs expression and prognosis in breast cancer., PMID:36206661
Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia-Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response., PMID:35783188
Natural COA water inhibits mitochondrial ROS-mediated apoptosis through Plk3 downregulation under STZ diabetic stress in pancreatic β-cell lines., PMID:35300109
System analysis of FHIT in LUAD and LUSC: The expression, prognosis, gene regulation network, and regulation targets., PMID:35254116
Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways., PMID:34517344
Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro., PMID:34204873
miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3., PMID:34107258
Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile., PMID:34080290
Modelling the Functions of Polo-Like Kinases in Mice and Their Applications as Cancer Targets with a Special Focus on Ovarian Cancer., PMID:34065956
RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients., PMID:33788972
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3., PMID:33514736
Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1., PMID:33175530
Non-mitotic functions of polo-like kinases in cancer cells., PMID:33171265
A review on kinases phosphorylating the carboxyl-terminal domain of RNA polymerase II-Biological functions and inhibitors., PMID:33142427
Analyses of expressions and prognostic values of Polo-like kinases in non-small cell lung cancer., PMID:32627077
Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6., PMID:32575753
PARP1 Is Required for ATM-Mediated p53 Activation and p53-Mediated Gene Expression after Ionizing Radiation., PMID:32551582
Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor., PMID:32232973
Drug design by machine-trained elastic networks: predicting Ser/Thr-protein kinase inhibitors' activities., PMID:32222890
Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract., PMID:31882756
Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells., PMID:31874443
Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling., PMID:31655629
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate., PMID:31649851
Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold., PMID:31629162
The role of polo-like kinase 3 in the response of BRAF-mutant cells to targeted anticancer therapies., PMID:31571292
Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents., PMID:31381325
For research use only. Not for human or drug use.
