Catalog No.
YHN32901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly191-Gly482
Predicted molecular weight
35.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H0B6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kinesin light chain 2, KLC 2, KLC2
The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration., PMID:40093101
Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans., PMID:40016327
Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis., PMID:39378988
The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans., PMID:39171448
The kinesin light chain-2, a target of mRNA stabilizing protein HuR, inhibits p53 protein phosphorylation to promote radioresistance in NSCLC., PMID:37055376
Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development., PMID:36576422
Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients., PMID:35559016
Dopey proteins are essential but overlooked regulators of membrane trafficking., PMID:35388894
Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human., PMID:34014435
A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis., PMID:33912899
GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα., PMID:32463939
Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358., PMID:31756096
Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti., PMID:30583735
Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations., PMID:30410084
Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3., PMID:30197037
Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons., PMID:30068641
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain., PMID:29036226
Vaccinia virus proteins A36 and F12/E2 show strong preferences for different kinesin light chain isoforms., PMID:28485852
The light chains of kinesin-1 are autoinhibited., PMID:26884162
Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome., PMID:26385635
Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network., PMID:25749990
High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients., PMID:25668010
Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP., PMID:25649263
Structural basis for kinesin-1:cargo recognition., PMID:23519214
Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms., PMID:22470497
Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation., PMID:22457801
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo., PMID:21996745
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome., PMID:21915095
A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors., PMID:20534517
Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export., PMID:20195521
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells., PMID:19773350
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration., PMID:19605495
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway., PMID:18996840
Insulin-induced GLUT4 movements in C2C12 myoblasts: evidence against a role of conventional kinesin motor proteins., PMID:18772605
Conventional kinesin holoenzymes are composed of heavy and light chain homodimers., PMID:18361505
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans., PMID:16236031
The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization., PMID:15563606
Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein., PMID:11969417
Kinesin light-chain KLC3 expression in testis is restricted to spermatids., PMID:11319135
Defective kinesin heavy chain behavior in mouse kinesin light chain mutants., PMID:10491391
Steady-state kinetics of skeletal muscle myosin light chain kinase indicate a strong down regulation by products., PMID:3841060
For research use only. Not for human or drug use.
