Catalog No.
YHJ53802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu80-Ala138
Predicted molecular weight
18.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9GZZ8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Extracellular glycoprotein lacritin, LACRT
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide., PMID:37620794
Lectin-Based Affinity Enrichment and Characterization of N-Glycoproteins from Human Tear Film by Mass Spectrometry., PMID:36677706
Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry., PMID:33921817
Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis., PMID:33187980
Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium., PMID:32859014
The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease., PMID:32274735
Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis., PMID:31009613
Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy., PMID:28419103
Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome., PMID:27711909
Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients., PMID:27436115
Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death., PMID:26670139
Lacritin and other autophagy associated proteins in ocular surface health., PMID:26318608
A thermo-responsive protein treatment for dry eyes., PMID:25481446
Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease., PMID:25034600
A cleavage-potentiated fragment of tear lacritin is bactericidal., PMID:24942736
Cytoprotective effect of lacritin on human corneal epithelial cells exposed to benzalkonium chloride in vitro., PMID:24401093
Lacritin and the tear proteome as natural replacement therapy for dry eye., PMID:23769845
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism., PMID:23640897
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., PMID:23504321
Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells., PMID:23482462
Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity., PMID:23425695
Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin., PMID:23422824
Pathogen induced changes in the protein profile of human tears from Fusarium keratitis patients., PMID:23308132
Gene expression in human accessory lacrimal glands of Wolfring., PMID:22956620
Tear lacritin levels by age, sex, and time of day in healthy adults., PMID:22918641
Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment., PMID:22871838
Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated., PMID:21087963
Lacritin and other new proteins of the lacrimal functional unit., PMID:18840430
Focus on molecules: lacritin., PMID:17412322
Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin., PMID:16982797
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways., PMID:16923831
Expression of a novel lacrimal gland gene lacritin in human breast tissues., PMID:14574570
Genetic separation of the human lacritin gene ("LACRT") and triple A (Allgrove) syndrome on 12q13., PMID:12613904
cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland., PMID:11419941
The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium., PMID:8648615
For research use only. Not for human or drug use.
