Catalog No.
YHN31701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His746-Asp812
Predicted molecular weight
35.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99570
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PI3-kinase regulatory subunit 4, PIK3R4, Phosphoinositide 3-kinase adaptor protein, VPS15, PI3-kinase p150 subunit, Phosphoinositide 3-kinase regulatory subunit 4
Structural pathway for PI3-kinase regulation by VPS15 in autophagy., PMID:39913640
Identification of Drug-Targetable Genes for Eczema and Dermatitis Using Integrated Genomic and Proteomic Approaches., PMID:39786806
Proteomic profiling identifies classic Hodgkin lymphoma patients at risk of bleomycin pulmonary toxicity., PMID:39625996
Integrating transcriptomics and proteomics to analyze the immune microenvironment of cytomegalovirus associated ulcerative colitis and identify relevant biomarkers., PMID:39192288
Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression., PMID:39116841
VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy., PMID:38762759
ULK1 seen at the single-molecule level during autophagy initiation., PMID:37992308
A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation., PMID:37942902
CD44 connects autophagy decline and ageing in the vascular endothelium., PMID:37684253
Cancer-Associated Fibroblasts Influence Survival in Pleural Mesothelioma: Digital Gene Expression Analysis and Supervised Machine Learning Model., PMID:37569808
Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)., PMID:37450577
The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs., PMID:37409929
A paradigm shift: AMPK negatively regulates ULK1 activity., PMID:37339275
A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation., PMID:36909501
The expression and prognostic significance of PIK3CB in lung adenocarcinoma., PMID:35780638
Phosphoinositide-3-kinase regulatory subunit 4 participates in the occurrence and development of amyotrophic lateral sclerosis by regulating autophagy., PMID:34916448
Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds., PMID:34861880
The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics., PMID:34520329
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy., PMID:34121209
Minimized combinatorial CRISPR screens identify genetic interactions in autophagy., PMID:33956155
How autophagy controls the intestinal epithelial barrier., PMID:33906557
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy., PMID:33779513
PRKAA/AMPKα phosphorylation switches the role of RASAL2 from a suppressor to an activator of autophagy., PMID:33563064
Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease., PMID:33459128
GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex., PMID:33222586
New insights regarding SNARE proteins in autophagosome-lysosome fusion., PMID:32924745
Selective autophagy inhibition through disruption of the PIK3C3-containing complex I., PMID:32619130
Trametenolic Acid B Triggers HSP90AA4P and Autophagy in HepG2/2.2.15 Cells by Proteomic Analysis., PMID:32548489
Harnessing Autophagic Network Is Essential for Trophoblast Stem Cell Differentiation., PMID:32143554
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease., PMID:32093570
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I., PMID:31696776
Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease., PMID:31564717
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy., PMID:31448672
Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1/PKC signaling pathway., PMID:31356904
Low-intensity pulsed ultrasound repair in mandibular condylar cartilage injury rabbit model., PMID:31174095
Identifying potential metastasis-related long non-coding RNAs, microRNAs, and message RNAs in the esophageal squamous cell carcinoma., PMID:30891809
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs., PMID:30767700
Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus-A Co-expression Network Based Analysis., PMID:30627105
Targeting AR-Beclin 1 complex-modulated growth factor signaling increases the antiandrogen Enzalutamide sensitivity to better suppress the castration-resistant prostate cancer growth., PMID:30423407
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1., PMID:30231667
The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation., PMID:30081750
ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis., PMID:30081747
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B., PMID:29778605
PIK3C3/VPS34 control by acetylation., PMID:28980854
Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex., PMID:28757208
Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis., PMID:28486006
Autophagy dysregulation in Danon disease., PMID:28102838
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy., PMID:28059666
A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi., PMID:27882921
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex., PMID:27630019
For research use only. Not for human or drug use.
