Catalog No.
YHN31301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly231-Asp470
Predicted molecular weight
29.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96TC7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein FAM82C, TCPTP-interacting protein 51, Regulator of microtubule dynamics protein 3, FAM82C, hRMD-3, Protein tyrosine phosphatase-interacting protein 51, RMDN3, Cerebral protein 10, FAM82A2, RMD-3, PTPIP51, Protein FAM82A2
Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases., PMID:40045432
Association of Inherited Genetic Variants with Multiple Primary Melanoma., PMID:40036058
ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress., PMID:39929810
Modulation of ER-mitochondria tethering complex VAPB-PTPIP51: Novel therapeutic targets for aging-associated diseases., PMID:38719161
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects., PMID:38395965
PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation., PMID:35240162
MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51., PMID:34964862
Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes., PMID:33938112
Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain., PMID:32682953
Identification of Methylated Gene Biomarkers in Patients with Alzheimer's Disease Based on Machine Learning., PMID:32309439
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity., PMID:31501572
Crosstalks of the PTPIP51 interactome revealed in Her2 amplified breast cancer cells by the novel small molecule LDC3/Dynarrestin., PMID:31075141
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity., PMID:30841933
The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51., PMID:30360441
Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling., PMID:28754031
ER-mitochondria signaling regulates autophagy., PMID:28548902
α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production., PMID:28337542
The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy., PMID:28132811
Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51)., PMID:27734150
ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations., PMID:27418313
ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function., PMID:27113756
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors., PMID:25999297
PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway., PMID:25893721
PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor., PMID:25862004
ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43., PMID:24893131
The known interactome of PTPIP51 in HaCaT cells—inhibition of kinases and receptors., PMID:24501773
PTPIP51 in protein interactions: regulation and in situ interacting partners., PMID:22544307
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis., PMID:22131369
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ., PMID:21972092
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia., PMID:21513978
Protein tyrosine phosphatase interacting protein 51--a jack-of-all-trades protein., PMID:21369858
PTPIP51-a myeloid lineage specific protein interacts with PTP1B in neutrophil granulocytes., PMID:20627780
PTPIP51 mRNA and protein expression in tissue microarrays and promoter methylation of benign prostate hyperplasia and prostate carcinoma., PMID:19691131
Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51., PMID:19491056
Differentiation-dependent PTPIP51 expression in human skeletal muscle cell culture., PMID:19124842
The novel protein PTPIP51 is expressed in human keratinocyte carcinomas and their surrounding stroma., PMID:19012732
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) mRNA expression and localization and its in vitro interacting partner protein tyrosine phosphatase 1B (PTP1B) in human placenta of the first, second, and third trimester., PMID:18854601
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway., PMID:18771726
Expression of the novel protein PTPIP51 in rat liver: an immunohistochemical study., PMID:17551746
Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes., PMID:17361080
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis., PMID:16820967
For research use only. Not for human or drug use.
