Catalog No.
YHN31201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser638-Leu854
Predicted molecular weight
26.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96T21
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SECISBP2, SECIS-binding protein 2, SBP2, Selenocysteine insertion sequence-binding protein 2
Understanding the role of tRNA modifications in UGA recoding as selenocysteine in eukaryotes., PMID:39988117
Severe neurodevelopmental phenotype, diagnostic, and treatment challenges in patients with SECISBP2 deficiency., PMID:39315526
Normal Values for the fT3/fT4 Ratio: Centile Charts (0-29 Years) and Their Application for the Differential Diagnosis of Children with Developmental Delay., PMID:39201272
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation., PMID:38042913
Cell Differentiation Trajectory Predicts Prognosis and Immunotherapeutic Response in Clear Cell Renal Cell Carcinoma., PMID:36530957
High-Resolution Ribosome Profiling Reveals Gene-Specific Details of UGA Re-Coding in Selenoprotein Biosynthesis., PMID:36291713
Establishment and verification of a prognostic model of liver cancer by RNA-binding proteins based on the TCGA database., PMID:36249884
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon., PMID:35709277
Inherited Disorders of Thyroid Hormone Metabolism Defect Caused by the Dysregulation of Selenoprotein Expression., PMID:35126314
The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer., PMID:34935169
Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency., PMID:34884733
Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation., PMID:34142161
RNA-Associated Co-expression Network Identifies Novel Biomarkers for Digestive System Cancer., PMID:33841514
Potential relationship between the selenoproteome and cancer., PMID:33133596
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma., PMID:33077808
Cardiac complications of thyroid hormone resistance syndromes., PMID:32513415
Identification of Resistance to Exogenous Thyroxine in Humans., PMID:32498666
Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency., PMID:32295391
Clinical and Molecular Analysis in 2 Families With Novel Compound Heterozygous SBP2 (SECISBP2) Mutations., PMID:32084277
Role of the Thyroid Gland in Expression of the Thyroid Phenotype of Sbp2-Deficient Mice., PMID:31826256
Apparent resistance to thyroid hormones: From biological interference to genetics., PMID:31590893
Iodothyronine deiodinases and reduced sensitivity to thyroid hormones., PMID:31585886
Gained in translation: The power of digging deep into disease models., PMID:31562227
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations., PMID:31350336
Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity., PMID:30815697
T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency., PMID:30596260
The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis., PMID:30286747
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage., PMID:30247797
A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish Boy., PMID:29882503
Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions., PMID:29709707
Identification of Genetic Disorders Causing Disruption of Selenoprotein Biosynthesis., PMID:28917055
In Vitro Translation Assays for Selenocysteine Insertion., PMID:28917039
Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway., PMID:28623977
SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation., PMID:28115638
The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay., PMID:27956496
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism., PMID:27473727
Targeted deletion of Secisbp2 reduces, but does not abrogate, selenoprotein expression and leads to striatal interneuron loss., PMID:26461424
Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene., PMID:26411970
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2., PMID:25692238
Hypermethylated-capped selenoprotein mRNAs in mammals., PMID:25013170
The SBP2 protein central to selenoprotein synthesis contacts the human ribosome at expansion segment 7L of the 28S rRNA., PMID:24850884
Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice., PMID:24844465
Inherited defects in thyroid hormone cell-membrane transport and metabolism., PMID:24629861
[Biosyinthesis and mechanism of selenocysteine incorporation into synthesized proteins]., PMID:24466745
Secisbp2 is essential for embryonic development and enhances selenoprotein expression., PMID:24274065
Different causes of reduced sensitivity to thyroid hormone: diagnosis and clinical management., PMID:23834164
A novel insight into the mechanism of mammalian selenoprotein synthesis., PMID:23788723
Identification of nucleotides and amino acids that mediate the interaction between ribosomal protein L30 and the SECIS element., PMID:23777426
The selenocysteine-specific elongation factor contains a novel and multi-functional domain., PMID:22992746
The syndromes of reduced sensitivity to thyroid hormone., PMID:22986150
For research use only. Not for human or drug use.
