Catalog No.
YHN30701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His41-Asp318
Predicted molecular weight
34.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96EU7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C1Gal-T2, Core 1 beta1,3-galactosyltransferase 2, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C38H2-L1, C1GALT1C1, COSMC, C38H2-like protein 1, Core 1 beta3-Gal-T2, C1GalT2, C1GALT1-specific chaperone 1
Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery., PMID:39981259
C1GALT1C1-Associated Mosaic Disorder of Glycosylation in a Female., PMID:39949072
Proteome-wide Mendelian randomization and single-cell sequencing analysis identify the association between plasma proteins and gastric cancer., PMID:39279974
Cosmc regulates O-glycan extension in murine hepatocytes., PMID:39216105
Substrate O-glycosylation actively regulates extracellular proteolysis., PMID:39074261
Targeting host O-linked glycan biosynthesis affects Ebola virus replication efficiency and reveals differential GalNAc-T acceptor site preferences on the Ebola virus glycoprotein., PMID:38757972
Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status., PMID:37237420
Germline C1GALT1C1 mutation causes a multisystem chaperonopathy., PMID:37216524
CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation., PMID:36648436
X-linked C1GALT1C1 mutation causes atypical hemolytic uremic syndrome., PMID:36599939
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease., PMID:36551160
Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19., PMID:35239653
Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure., PMID:34644263
Expression profile of Fc receptor-like molecules in patients with IgA nephropathy., PMID:33597097
CD44-Associated Tn Antigen as a New Biomarker of Tumor Cells with Aberrant Glycosylation., PMID:33050853
O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization., PMID:32692906
The Cosmc-mediated effects of neutrophil elastase on T antigen expression in BEAS-2B cells., PMID:32683071
Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity., PMID:32517158
Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans., PMID:32452513
MicroRNA‑196b targets COSMC in pediatric IgA nephropathy., PMID:32186752
Effects of non-caloric ultrashort wave on the expression of CoQ10 and C1GALT1C1 in rats with cerebral ischemia reperfusion injury., PMID:32132294
C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy., PMID:31941451
Cosmc overexpression enhances malignancies in human colon cancer., PMID:31633299
C1GALT1C1/COSMC is a novel prognostic biomarker for hepatocellular carcinoma., PMID:31471227
Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells., PMID:31389667
Cosmc is required for T cell persistence in the periphery., PMID:31317176
Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression., PMID:31250447
Corticosteroid therapy in IgA nephropathy with minimal proteinuria and high renal pathological score: A single‑center cohort study., PMID:30132546
Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers., PMID:30115016
Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours., PMID:30011875
Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer., PMID:29999571
A genome-wide survey of mutations in the Jurkat cell line., PMID:29739316
Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells., PMID:29299950
Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents., PMID:29276373
MiR-320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathy., PMID:29266359
CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter., PMID:28708980
Biochemical characterization of functional domains of the chaperone Cosmc., PMID:28665962
GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway., PMID:28187132
TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc., PMID:28035353
MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy., PMID:27796698
Tumor-associated antigens: Tn antigen, sTn antigen, and T antigen., PMID:27679419
The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn., PMID:27542280
Potential diagnostic biomarkers for IgA nephropathy: a comparative study pre- and post-tonsillectomy., PMID:27465795
[Association of Cosmc gene mutation with susceptibility to Henoch-Schönlein purpura in children]., PMID:27412546
Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated IgA1 in B cells of IgA nephropathy., PMID:26545495
Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation., PMID:26063800
Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29., PMID:26045765
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer., PMID:26021314
DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy., PMID:25647400
Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases., PMID:25479423
For research use only. Not for human or drug use.
