Catalog No.
YHN30101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val2-Glu59
Predicted molecular weight
19.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96B97
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD2-binding protein 3, Human Src family kinase-binding protein 1, SH3KBP1, HSB-1, Cbl-interacting protein of 85 kDa, CIN85, SH3 domain-containing kinase-binding protein 1, CD2BP3
Targets and Potential Mechanism of Chondroitin Sulfate A-selenium Nanoparticle on Kashin-Beck Disease Chondrocytes., PMID:40138104
SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrity., PMID:40065183
Feature gene selection and functional validation of SH3KBP1 in infantile hemangioma using machine learning., PMID:39955954
Proteomic analysis of the nonstructural protein 2-host protein interactome reveals a novel regulatory role of SH3 domain-containing kinase-binding protein 1 in porcine reproductive and respiratory syndrome virus replication and apoptosis., PMID:39755310
Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I., PMID:39466846
Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma., PMID:39448713
The microprotein HDSP promotes gastric cancer progression through activating the MECOM-SPINK1-EGFR signaling axis., PMID:39333095
A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study., PMID:38033384
Targeting of insulin receptor endocytosis as a treatment to insulin resistance., PMID:37788593
CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice., PMID:37343421
Screening crucial lncRNAs and genes in osteoarthritis by integrated analysis., PMID:36849988
Identification of Two CDK5R1-Related Subtypes and Characterization of Immune Infiltrates in Alzheimer's Disease Based on an Integrated Bioinformatics Analysis., PMID:36561735
Identifying transcript-level differential expression in primary human immune cells., PMID:36527757
An unusual familial Xp22.12 microduplication including EIF1AX: A novel candidate dosage-sensitive gene for premature ovarian insufficiency., PMID:36113757
ADAPTOR PROTEIN Ruk/CIN85REGULATES REDOX BALANCE IN 4T1MOUSE BREAST CANCER CELLS EXPOSED TO PLASMIN(OGEN)., PMID:35548969
Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study., PMID:34344401
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells., PMID:33763075
Exploring Molecular Contacts of MUC1 at CIN85 Binding Interface to Address Future Drug Design Efforts., PMID:33672244
SH3KBP1 Promotes Glioblastoma Tumorigenesis by Activating EGFR Signaling., PMID:33643898
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis., PMID:33627783
In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain., PMID:33430321
High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma., PMID:33179079
LncRNA ARAP1-AS2 promotes high glucose-induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1., PMID:32969198
Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness., PMID:32051419
Oral exposure to low-dose bisphenol A induces hyperplasia of dorsolateral prostate and upregulates EGFR expression in adult Sprague-Dawley rats., PMID:31771501
Mutations in Hypervariable Domain of Venezuelan Equine Encephalitis Virus nsP3 Protein Differentially Affect Viral Replication., PMID:31694937
Computational analysis of functional SNPs in Alzheimer's disease-associated endocytosis genes., PMID:31592138
Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein., PMID:31493651
The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2., PMID:31142511
Inhibition of T cell activation and function by the adaptor protein CIN85., PMID:30723173
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency., PMID:30089695
Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus., PMID:29702546
Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency., PMID:29636373
Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85., PMID:29589748
Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring., PMID:29158391
Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation., PMID:28966118
Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets., PMID:28876503
Efficient invasion by Toxoplasma depends on the subversion of host protein networks., PMID:28848228
Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma., PMID:28601352
Cbl E3 Ligase Mediates the Removal of Nectin-1 from the Surface of Herpes Simplex Virus 1-Infected Cells., PMID:28381567
CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes., PMID:27531950
The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation., PMID:27353366
A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling., PMID:27334924
Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85., PMID:29227594
Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer., PMID:26206335
CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface., PMID:26169354
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma MCF-7 cells., PMID:25816594
SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR., PMID:25472714
Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis., PMID:25449262
MAGI-2 scaffold protein is critical for kidney barrier function., PMID:25271328
For research use only. Not for human or drug use.
