Catalog No.
YHN29801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys17-Asp187
Predicted molecular weight
21.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92879
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CELF-1, CUGBP1, CUGBP Elav-like family member 1, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, EDEN-BP homolog, CELF1, RNA-binding protein BRUNOL-2, 50 kDa nuclear polyadenylated RNA-binding protein, CUG triplet repeat RNA-binding protein 1, BRUNOL2, CUGBP, NAB50, CUG-BP- and ETR-3-like factor 1, Bruno-like protein 2, CUG-BP1
CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2., PMID:40021568
A small interfering RNA inhibits lung fibroblast-myofibroblast differentiation via simultaneously knockingdown CELF1 and activating RIG-I signalling., PMID:39993608
RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer., PMID:39456596
Multivalent Protein-Nucleic Acid Interactions Probed by Composition-Gradient Multiangle Light Scattering., PMID:39371993
Noncoding Vault RNA1-1 Impairs Intestinal Epithelial Renewal and Barrier Function by Interacting With CUG-binding Protein 1., PMID:39349247
PKC-mediated phosphorylation governs the stability and function of CELF1 as a driver of EMT in breast epithelial cells., PMID:39343007
Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1-RNA interaction., PMID:39268573
Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing., PMID:38768546
Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight muscles., PMID:38683844
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review., PMID:38443798
circGlis3 promotes β-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein., PMID:38226164
CIZ1 in Xist seeded assemblies at the inactive X chromosome., PMID:38155839
Eye Lens Organoids Made Simple: Characterization of a New Three-Dimensional Organoid Model for Lens Development and Pathology., PMID:37887322
Differentially Expressed mRNA in Streptozotocin-Induced Diabetic Bladder Using RNA Sequencing Analysis., PMID:37798882
Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model., PMID:37797921
Eye lens organoids going simple: characterization of a new 3-dimensional organoid model for lens development and pathology., PMID:37503005
High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology., PMID:37048143
miR-322 promotes the differentiation of embryonic stem cells into cardiomyocytes., PMID:36932296
Glycyrrhizic acid alleviates liver fibrosis in vitro and in vivo via activating CUGBP1-mediated IFN-γ/STAT1/Smad7 pathway., PMID:36805480
Extracellular vesicles secreted by adenomyosis endometrial organoids contain miRNAs involved in embryo implantation and pregnancy., PMID:36697316
CELF1 Selectively Regulates Alternative Splicing of DNA Repair Genes Associated With Cataract in Human Lens Cell Line., PMID:36585568
CELF1 represses Doublesex1 expression via its 5' UTR in the crustacean Daphnia magna., PMID:36240182
Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury., PMID:36214222
The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the alternative splicing of CD44., PMID:35973378
Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy., PMID:35567413
ErbB4 alternative splicing mediates fetal mouse alveolar type II cell differentiation in vitro., PMID:35338350
CELF1 promotes matrix metalloproteinases gene expression at transcriptional level in lens epithelial cells., PMID:35287612
Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis., PMID:35234905
RNA binding protein CUGBP1 mediates the liver metastasis of colorectal cancer by regulating the ErbB signal pathway., PMID:35116643
Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma., PMID:35017650
Distribution of alternative untranslated regions within the mRNA of the CELF1 splicing factor affects its expression., PMID:34996980
RNA-binding proteins and post-transcriptional regulation in lens biology and cataract: Mediating spatiotemporal expression of key factors that control the cell cycle, transcription, cytoskeleton and transparency., PMID:34906599
Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis., PMID:34788230
DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis., PMID:34697393
RNA-binding protein CELF1 promotes cardiac hypertrophy via interaction with PEBP1 in cardiomyocytes., PMID:34669021
lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity., PMID:34492818
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation., PMID:33845055
CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure., PMID:33811692
LncRNA BACE1-AS enhances the invasive and metastatic capacity of hepatocellular carcinoma cells through mediating miR-377-3p/CELF1 axis., PMID:33667514
miR-322/miR-503 clusters regulate defective myoblast differentiation in myotonic dystrophy RNA-toxic by targeting Celf1., PMID:33613970
SP1-induced AFAP1-AS1 contributes to proliferation and invasion by regulating miR-497-5p/CELF1 pathway in nasopharyngeal carcinoma., PMID:33400247
Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development., PMID:33297405
DeepA-RBPBS: A hybrid convolution and recurrent neural network combined with attention mechanism for predicting RBP binding site., PMID:33272122
The hallmarks of myotonic dystrophy type 1 muscle dysfunction., PMID:33269537
A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity., PMID:33189700
CELF2 regulates the species-specific alternative splicing of TREM2., PMID:33093587
miR-322/-503 rescues myoblast defects in myotonic dystrophy type 1 cell model by targeting CUG repeats., PMID:33093470
An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type I., PMID:32971903
A protein assembly mediates Xist localization and gene silencing., PMID:32908311
For research use only. Not for human or drug use.
