Catalog No.
YHN29701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg710-Thr972
Predicted molecular weight
32.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92622
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RUBCN, KIAA0226, Beclin-1 associated RUN domain containing protein, Rubicon, Baron, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
[Advances in the study of viruses inhibiting the production of advanced autophagy or interferon through Rubicon to achieve innate immune escape]., PMID:39799430
Rubicon regulates exosome secretion via the non-autophagic pathway., PMID:39667388
PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense., PMID:39578445
WSSV induces Rubicon expression to regulate innate immune response in Penaeus vannamei., PMID:39571631
A second RUBCN variant associated with epileptic encephalopathy and neurodevelopmental delay., PMID:39520129
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells., PMID:39032560
LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma., PMID:38806658
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy., PMID:38728007
ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4+ Th1 responses., PMID:38368631
Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule., PMID:38362917
Enhancement of LC3-associated efferocytosis for the alleviation of intestinal inflammation., PMID:38311819
Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer., PMID:38307028
Opposing roles of RUBCN isoforms in autophagy and memory B cell generation., PMID:37725663
CX3CL1 represses autophagy via CX3CR1/ CaMKIIδ/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis., PMID:37640194
Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD?, PMID:37482676
The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs., PMID:37409929
IL-27 inhibits anti- Mycobacterium tuberculosis innate immune activity of primary human macrophages., PMID:36863206
Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease., PMID:36476132
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia., PMID:36288210
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice., PMID:36280666
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation., PMID:36170234
Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease., PMID:35740989
Rubicon promotes the M2 polarization of Kupffer cells via LC3-associated phagocytosis-mediated clearance to improve liver transplantation., PMID:35700602
DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis., PMID:35641782
Acetylation in the regulation of autophagy., PMID:35435793
Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury., PMID:35288534
Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response., PMID:35282767
Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis., PMID:35192551
Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis., PMID:35025696
Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload., PMID:34996972
A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation., PMID:34965300
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC., PMID:34932879
Autophagy deficiency activates rDNA transcription., PMID:34612149
METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease., PMID:34547464
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function., PMID:34351902
Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide., PMID:33988680
Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis., PMID:33960279
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death., PMID:33854187
Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration., PMID:33740621
Acanthopanax senticosus Harms extract causes G0/G1 cell cycle arrest and autophagy via inhibition of Rubicon in human liver cancer cells., PMID:33650674
Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy., PMID:33239448
Autophagy and Lc3-Associated Phagocytosis in Zebrafish Models of Bacterial Infections., PMID:33138004
Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation., PMID:32943718
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy., PMID:32811819
Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance., PMID:32669482
Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex., PMID:32632011
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1., PMID:32543276
Ancient founder mutation in RUBCN: a second unrelated family confirms Salih ataxia (SCAR15)., PMID:32450808
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury., PMID:32364533
CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly., PMID:32248306
For research use only. Not for human or drug use.
