Catalog No.
YHN29501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser137-Gln305
Predicted molecular weight
21.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WV24
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, Pleckstrin homology-like domain family A member 1, PQR protein, Apoptosis-associated nuclear protein, PHRIP, PHLDA1, Proline- and glutamine-rich protein, TDAG51, PQ-rich protein
Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength., PMID:40295915
Identification and validation of susceptibility modules and hub genes in polyarticular juvenile idiopathic arthritis using WGCNA and machine learning., PMID:39699225
Expanding on roles of pleckstrin homology-like domain family A member 1 protein., PMID:39630301
PHLDA1 protects intestinal barrier function via restricting intestinal epithelial cells apoptosis in inflammatory bowel disease., PMID:39510153
The G-Protein-Coupled Estrogen Receptor Agonist G-1 Mediates Antitumor Effects by Activating Apoptosis Pathways and Regulating Migration and Invasion in Cervical Cancer Cells., PMID:39409923
Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights., PMID:39089476
The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer., PMID:39027611
PHLDA1-PRDM1 mediates the effect of lentiviral vectors on fate-determination of human retinal progenitor cells., PMID:39012348
Multiomics Analysis of the PHLDA Gene Family in Different Cancers and Their Clinical Prognostic Value., PMID:38921000
Single-cell profiling reveals the metastasis-associated immune signature of hepatocellular carcinoma., PMID:38780041
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy., PMID:38750074
Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage., PMID:38652514
Silencing of the PHLDA1 leads to global proteome changes and differentiation pathways of human neuroblastoma cells., PMID:38495105
Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice., PMID:38237682
Exploring NK-Cell molecules that impact the immune response and microenvironment in head and neck squamous cell carcinoma., PMID:38011007
Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis., PMID:37749575
Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation., PMID:37695229
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis., PMID:37225844
TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses., PMID:37203866
PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis., PMID:37155089
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction., PMID:37047202
Protective effect of basic helix-loop-helix family member e40 on cerebral ischemia/reperfusion injury: Inhibition of apoptosis via repressing the transcription of pleckstrin homology-like domain family A, member 1., PMID:36881362
PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage., PMID:36875102
PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARγ in cerebral ischemia-reperfusion injury., PMID:36681251
Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling., PMID:36576246
Genomewide m6A Mapping Uncovers Dynamic Changes in the m6A Epitranscriptome of Cisplatin-Treated Apoptotic HeLa Cells., PMID:36497162
Optimized Transcriptional Signature for Evaluation of MEK/ERK Pathway Baseline Activity and Long-Term Modulations in Ovarian Cancer., PMID:36362153
PHLDA1 knockdown inhibits inflammation and oxidative stress by regulating JNK/ERK pathway, and plays a protective role in sepsis-induced acute kidney injury., PMID:36335439
Single-Cell Transcriptomic Profiling of Human Retinal Organoids Revealed a Role of IGF1-PHLDA1 Axis in Photoreceptor Precursor Specification., PMID:36331259
[Research Progress of Pleckstrin Homology Like Domain Family A Member 1 in Tumor]., PMID:36325784
DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics., PMID:36289533
PHLDA1 promotes sevoflurane-induced pyroptosis of neuronal cells in developing rats through TRAF6-mediated activation of Rac1., PMID:36155068
Loss of Pleckstrin homology like domain, family A, member 1 promotes type Ⅱ alveolar epithelial cell apoptosis in chronic obstructive pulmonary disease emphysematous phenotype via interaction with tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon., PMID:36108948
PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras., PMID:36107262
Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T-lymphocytes: A bioinformatic analysis., PMID:36092920
Predicting potential biomarkers and immune infiltration characteristics in heart failure., PMID:35942730
Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer., PMID:35831322
Integrative bioinformatics analysis of potential therapeutic targets and immune infiltration characteristics in dilated cardiomyopathy., PMID:35433958
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip., PMID:35237256
Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease., PMID:35218958
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway., PMID:35175494
PHLDA1 Blockade Alleviates Cerebral Ischemia/Reperfusion Injury by Affecting Microglial M1/M2 Polarization and NLRP3 Inflammasome Activation., PMID:35093445
Recurrent FOXK1::GRHL and GPS2::GRHL fusions in trichogerminoma., PMID:35049062
Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1., PMID:34847273
Immune Characteristics Analysis and Transcriptional Regulation Prediction Based on Gene Signatures of Chronic Obstructive Pulmonary Disease., PMID:34764646
TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease., PMID:34625532
PHLDA1 Modulates the Endoplasmic Reticulum Stress Response and is required for Resistance to Oxidative Stress-induced Cell Death in Human Ovarian Cancer Cells., PMID:34405011
PHLDA1 expression in ulcerative colitis: A potential role in the management of dysplasia., PMID:34349991
Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations., PMID:34232601
BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer., PMID:33982211
For research use only. Not for human or drug use.
