Catalog No.
YHK27001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2131-Asp2337
Predicted molecular weight
26.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NG31
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Blinkin, CT29, Kinetochore-null protein 1, Cancer/testis antigen 29, Bub-linking kinetochore protein, Protein CASC5, Protein D40/AF15q14, ALL1-fused gene from chromosome 15q14 protein, Kinetochore scaffold 1, CASC5, KNL1, Cancer susceptibility candidate gene 5 protein, KIAA1570, AF15q14
Arabidopsis KNL1 recruits type one protein phosphatase to kinetochores to silence the spindle assembly checkpoint., PMID:39908360
The KNL-1/Knl1 outer kinetochore protein caught regulating F-actin., PMID:39820668
The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching., PMID:39625434
Fibrous corona is reduced in cancer cell lines that attenuate microtubule nucleation from kinetochores., PMID:39604214
Golgin45 assists mitosis via its nuclear localization sequence., PMID:39442450
Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression., PMID:39356777
Artificial kinetochore beads establish a biorientation-like state in the spindle., PMID:39298589
Distinct patterns of satDNA distribution in holocentric chromosomes of spike-sedges (Eleocharis, Cyperaceae)., PMID:39284229
Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes., PMID:38865189
Kaempferol from Alpinia officinarum hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway., PMID:38857680
The holocentricity in the dioecious nutmeg (Myristica fragrans) is not based on major satellite repeats., PMID:38717688
The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system., PMID:38656792
Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores., PMID:38578284
Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes., PMID:38559067
Structure of the human KMN complex and implications for regulation of its assembly., PMID:38459128
Structure of the human outer kinetochore KMN network complex., PMID:38459127
Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274
KNL1 and NDC80 represent new universal markers for the detection of functional centromeres in plants., PMID:38403686
Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores., PMID:38370671
Neocortical neurogenesis in development and evolution-Human-specific features., PMID:38189676
Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression., PMID:38187612
Multimerization of a disordered kinetochore protein promotes accurate chromosome segregation by localizing a core dynein module., PMID:38180477
A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis., PMID:38170753
A novel KNL1 intronic splicing variant likely destabilizes the KMN complex, causing primary microcephaly., PMID:37937525
Role of Kinetochore Scaffold 1 (KNL1) in Tumorigenesis and Tumor Immune Microenvironment in Pan-Cancer: Bioinformatics Analyses and Validation of Expression., PMID:37928953
Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration., PMID:37905452
Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion., PMID:37782660
A bifunctional kinase-phosphatase module balances mitotic checkpoint strength and kinetochore-microtubule attachment stability., PMID:37712330
A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities., PMID:37661832
Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere., PMID:37506202
Analysis of the Mutational Landscape of Osteosarcomas Identifies Genes Related to Metastasis and Prognosis and Disrupted Biological Pathways of Immune Response and Bone Development., PMID:37445641
Cortical microtubules oppose actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion., PMID:37292632
An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome segregation by dynein., PMID:37214933
Disruption of the standard kinetochore in holocentric Cuscuta species., PMID:37192159
A mechanism that integrates microtubule motors of opposite polarity at the kinetochore corona., PMID:37163019
Integrative Analysis of DNA Methylation and Gene Expression Data Identifies Potential Biomarkers and Functional Epigenetic Modules for SARS-CoV-2., PMID:37017853
The Loss-Function of KNL1 Causes Oligospermia and Asthenospermia in Mice by Affecting the Assembly and Separation of the Spindle through Flow Cytometry and Immunofluorescence., PMID:36904774
KNL1 is a prognostic and diagnostic biomarker related to immune infiltration in patients with uterine corpus endometrial carcinoma., PMID:36776306
Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway., PMID:38583438
Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development., PMID:35905187
The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals., PMID:35816093
BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling., PMID:35767360
MEL-28/ELYS and CENP-C coordinately control outer kinetochore assembly and meiotic chromosome-microtubule interactions., PMID:35609608
Identification of a Five-Gene Panel to Assess Prognosis for Gastric Cancer., PMID:35187167
Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation., PMID:35167144
Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore., PMID:35042402
Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling., PMID:34861183
The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction., PMID:34705493
Inhibiting microcephaly genes as alternative to microtubule targeting agents to treat brain tumors., PMID:34663805
Impact of KMN network genes on progression and prognosis of non-small cell lung cancer., PMID:34419962
For research use only. Not for human or drug use.
