Catalog No.
YHN28101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser143-Ser399
Predicted molecular weight
30.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86YH6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
All-trans-decaprenyl-diphosphate synthase subunit 2, Solanesyl-diphosphate synthase subunit 2, C6orf210, PDSS2, DLP1, Decaprenyl-diphosphate synthase subunit 2, Candidate tumor suppressor protein, All trans-polyprenyl-diphosphate synthase PDSS2, Decaprenyl pyrophosphate synthase subunit 2
The role of NRF2 function and regulation in atherosclerosis: an update., PMID:40025257
Putamen dopaminergic dysfunction is associated with sleep disturbance in drug-naïve patients with Parkinson's disease., PMID:39999701
Invasive therapies for Parkinson's disease: an adapted excerpt from the guidelines of the German Society of Neurology., PMID:39985674
Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm., PMID:39917016
Modelling the human coenzyme Q deficiency in Drosophila melanogaster., PMID:39864756
Overexpression of PDSS2-Del2 in HCC promotes tumor metastasis by interacting with macrophages., PMID:39695147
Alterations in coenzyme Q10 status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis., PMID:38960080
Identification of genomic diversity and selection signatures in Luxi cattle using whole-genome sequencing data., PMID:38271971
Metabolic programs of T cell tissue residency empower tumour immunity., PMID:37648857
SKA2-mediated transcriptional downregulation of the key enzyme of CoQ10 biosynthesis PDSS2 in lung cancer cells., PMID:36860919
Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson's disease focusing on correlations with motor symptoms., PMID:35220508
Levels of Coenzyme Q10 and Several COQ Proteins in Human Astrocytoma Tissues Are Inversely Correlated with Malignancy., PMID:35204836
Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells., PMID:34349107
Pimenta dioica and Pimenta racemosa: GC-based metabolomics for the assessment of seasonal and organ variation in their volatile components, in silico and in vitro cytotoxic activity estimation., PMID:33988201
PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in Atherosclerosis by Activating Nrf2., PMID:33929387
Re-evaluation of single nucleotide variants and identification of structural variants in a cohort of 45 sudden unexplained death cases., PMID:33895855
Identification of Predictive Biomarkers of Response to HSP90 Inhibitors in Lung Adenocarcinoma., PMID:33802597
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease., PMID:33444290
PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB., PMID:33064899
Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q10 levels and each other's stability., PMID:32194061
Effect of ALDH2 on Sleep Disturbances in Patients with Parkinson's Disease., PMID:31831791
Sp1 Mediates the Constitutive Expression and Repression of the PDSS2 Gene in Lung Cancer Cells., PMID:31783675
Model system identification of novel congenital heart disease gene candidates: focus on RPL13., PMID:31625562
A Systematic Analysis of Major Susceptible Genes in Childhood-onset Steroid-resistant Nephrotic Syndrome., PMID:31308032
The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency., PMID:28790927
Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway., PMID:27856618
A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration., PMID:26459857
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease., PMID:26041819
Decaprenyl diphosphate synthase subunit 2 as a prognosis factor in hepatocellular carcinoma., PMID:25780306
Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease., PMID:25514360
Decreased expression of prenyl diphosphate synthase subunit 2 correlates with reduced survival of patients with gastric cancer., PMID:25330808
[Progress in mitochondrial nephropathy]., PMID:25224054
Clinical utility of PDSS2 expression to stratify patients at risk for recurrence of hepatocellular carcinoma., PMID:25189544
Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error., PMID:25032733
The tumor-suppressing activity of the prenyl diphosphate synthase subunit 2 gene in lung cancer cells., PMID:24608273
Decrease of PDSS2 expression, a novel tumor suppressor, in non-small cell lung cancer., PMID:23312889
Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice., PMID:23150520
Refractory epilepsy and mitochondrial dysfunction due to GM3 synthase deficiency., PMID:22990144
Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ 10)., PMID:22231380
Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice., PMID:21983691
Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome., PMID:20507940
Cross-platform expression microarray performance in a mouse model of mitochondrial disease therapy., PMID:19944634
Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line., PMID:19209031
Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2., PMID:18784258
Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency., PMID:18230681
Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations., PMID:17186472
For research use only. Not for human or drug use.
